Browsing Human- und Zahnmedizin by Referee "Wirths, Oliver PD Dr."
Now showing items 1-7 of 7
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Untersuchung der Wirkung des antiaggregativen Compounds anle138b auf Löslichkeit und Toxizität von mutierter SOD1
(2017-11-02)Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the upper and lower motoneuron with flabby and spastic paralysis leading to death within three to five years because of respiratory insufficiency. ... -
In-vivo-Screen verschiedener Aggregationsmodulatoren in transgenen Drosophila melanogaster Alzheimermodellen
(2017-01-27)This study was aimed at evaluating different modulators of amyloid-beta aggregation in Drosophila melanogaster models of Alzheimer’s disease. Fly model studies are cost-effective and fast in vivo systems to screen therapeutic ... -
Quantitative analysis of neuropathological alterations in two transgenic mouse models of Alzheimer's disease
(2016-11-03)Mouse models of Alzheimer’s Disease (AD) contribute a lot to the understanding of etiology and pathology of AD. However, the entire clinical and neuropathological pictures of familial or sporadic AD in humans cannot be ... -
Über die Interaktionen des zellulären Prion-Proteins (PrPc) mit relevanten Proteinen der Alzheimer Erkrankung
(2014-07-08)Previous studies indicate an important role for the cellular prion Protein (PrPc) in the development of Alzheimer's disease pathology. In the present study the interaction of PrPc with Alzheimer relevant proteins such as ... -
Einfluss des Proteinaggregationshemmstoffs anle138b auf Beginn und Verlauf der Amyotrophen Lateralsklerose im transgenen hSOD1-Mausmodell
(2014-05-06)1. Review Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which the degeneration of the first and the second motor neuron is responsible for spastic and atonic paresis. The incidence of ALS is 2 of ... -
Liquorproteomveränderungen bei Patienten mit Lewy-Körperchen Demenz
(2013-08-23)Dementia with Lewy bodies (DLB) is a neurodegenerative disorder that is known to be one of the most common causes of dementia in the elderly. DLB patients clinically present with a rapid cognitive decline as well as one ... -
Die Neurogenese im Hippokampus und der subventrikulären Zone bei bakterieller Meningitis
(2012-09-12)Bacterial meningitis, particularly pneumococcal meningitis, is a severe disease characterized by a high mortality rate due to its association with complications and long-term cognitive deficits. Early antibiotic treatment ...