Browsing Human- und Zahnmedizin by Referee "Wouters-Bunt, Freddy Prof. Dr."
Now showing items 1-6 of 6
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Multiplexing Mikroskopie für B-Zell-Differenzierung in humanen Multiple Sklerose-Läsionen
(2023-04-13)The aim of this project was to show that with the help of lifetime imaging the specific differentitation of immune cells via their CD expression patterns becomes possible. It was shown that with a double staining of CD20 ... -
Die anaplastische Lymphomkinase (ALK) im Fokus der genomischen Instabilität des Neuroblastoms: Funktionale und morphometrische Untersuchungen
(2020-11-13)Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the family of insulin receptors. It is considered to be a potential driver for the development of neuroblastoma, a complex and often therapy-resistant ... -
Evaluation der Interaktionen zwischen extrazellulärer Matrix und ausgewählten tumorassoziierten Proteinen mittels Nahinfrarot-Antikörpern
(2020-10-23)The interplay between tumor cells and their microenvironment is crucial for carcinogenesis and tumor progression. In my thesis, I examine selected tumor-associated proteins that interact with the extracellular matrix ... -
Quantitative mikroskopische Analyse der Regulationsmechanismen der Anaplastic Lymphoma Kinase in Neuroblastomzellen
(2020-01-09)The anaplastic lymphoma kinase (ALK) plays an essential role in the pathogenesis of neuroblastoma. While the structure of the ALK-receptor as well as point mutations within the primary amino acid sequence of the receptor ... -
FRET-Bildgebung zum Nachweis der Phopshorylierung der anaplastic lymhoma kinase (ALK) im nicht-kleinzelligen Bronchialkarzinom
(2018-05-22)Background: Anaplastic lymphoma kinase (ALK) is an oncogenic driver mutation in T-cell lymphoma and NSCLC. Small molecule inhibitors are available. Treatment decisions are mostly made on ALK expression but their efficacy ... -
Therapeutischer Einfluss des Radikalfängers Trolox in einem Mausmodell für das Rett-Syndrom: Bewertung oxidativer Stressmarker in zerebralem Gewebe
(2017-05-10)The aim of this work was to assess a variety of phenotypic and biochemical features in a mouse model of Rett-syndrome, which was treated in vivo with the free radical scavenger Trolox. Rett-syndrome is a postnatal progressive ...