Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Brose, Nils Prof. Dr."
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NMR Spectroscopic studies of calmodulin plasticity in calcium signalling
(2008-03-18)The present work focused both in structural and dynamic studies on the ubiquitous Ca2+ signaling protein calmodulin. Calmodulin has been extensively studied both for its biological importance in the regulation of its ... -
NOVEL APPROACHES TO MODELING AND TREATMENT OF COGNITIVE DEFICITS IN NEUROPSYCHIATRIC DISEASES
(2010-10-15)Cognitive deficits and impairments of higher brain functions are the most burdening features in various neuropsychiatric disorders (e.g. Elvevag and Goldberg, 2000). Up to now, there are ... -
Profiling the inherent vulnerability of motor neuron subtypes
(2012-01-05)Motor neuron diseases (MNDs) are a heterogeneous group of disorders that result in selective degeneration of upper and/or lower motor neurons (MNs). The precise causes of most MNDs remain ... -
Resolving the Ultrastructural Organization of Synaptic Vesicle Pools at Hippocampal Mossy Fiber and Schaffer Collateral Synapses
(2021-02-18)The synapse is the functional unit of chemical communication between neurons in the brain. In order to relay information with spatiotemporal precision, the presynaptic compartment utilizes a specialized molecular machinery ... -
Role of chromatin remodelling BAF complex in fate regulation of ventral neural stem cells in the developing telencephalon
(2021-01-14)A role for the multi-subunit BAF (mammalian SWI/SNF) complex in brain development has been postulated as its dysfunction causes several neurological diseases, including intellectual disability, schizophrenia, autism spectrum ... -
Role of myelin-associated NAD+- dependent deacetylase Sirtuin 2 in modifying axonal degeneration
(2013-01-25)In the central nervous system (CNS), oligodendrocytes (OLs) ensheath axons with lipid-rich myelin membranes that provide an electrical insulation and are essential for fast nerve impulse transmission. However, myelination ... -
Role of Smad-interacting Protein 1 (Sip1/Zfhx1b) in the development of the cerebral cortex
(2006-05-19)Smad-interacting protein 1 (Sip1/Zfhx1b) is a transcription factor that has been previously implicated in TGF-β/BMP signaling and in the etiology of the Mowat-Wilson syndrome. The expression ... -
Role of the mGRIP1 homologue DGrip in the Drosophila neuromuscular system
(2005-07-05)Here, the identification and characterisation of the Drosophila homologue of the Glutamate Receptor Interacting Protein, DGrip is described. Mutants of DGrip show four scorable defects, a ... -
Serum Lipocalin-2 (LCN-2) as a major acute phase protein under different pathological conditions in vivo and in vitro studies
(2012-02-28)Lipocalin-2 (LCN-2) is a pleiotropic 25-kDa secretory protein, currently used as a biomarker for renal injury and inflammation. Its serum level is increased under different pathological ... -
SNARE assembly and regulation on membranes
(2006-08-01)The fusion of synaptic vesicles with the pre-synaptic plasma membrane is mediated by SNARE proteins. This work provides key insights into the behaviour of synaptobrevin, the SNARE protein ... -
Synaptic Targeting of Neurotransmitter Receptors is Regulated by Neurobeachin
(2011-11-14)In neuronal network, information is transferred mainly via chemical synapses. Typically, a neuron receives thousands of inputs, which are transmitted by the activation of a large number of ... -
Targeting gene therapy to neuroinfalmmatory lesions in experimental autoimmune encephalomyelitis
(2005-03-18)The blood-brain barrier (BBB) protects the central nervous system (CNS) from harmful substances but at the same time is an obstacle to therapy by blocking the transport of drugs into brain ... -
The establishment and characterization of an improved cell-free assay for exocytosis in neuroendocrine PC12 cells
(2005-11-04)Regulated exocytosis in neurons and neuroendocrine cells is mediated by the SNARE proteins synaptobrevin/VAMP, SNAP-25, and syntaxin 1. During fusion, these SNAREs form a stable complex ... -
The PI5P 4-kinase ortholog PPK-2 of Caenorhabditis elegans acts in synaptic transmission and neuronal membrane trafficking
(2010-06-28)Synaptic transmission relies on the tightly regulated membrane transport between the neuronal cell body and the nerve terminal. Important regulators of membrane trafficking in neurons as ... -
The presynaptic protein Mover buffers synaptic plasticity at the hippocampal mossy fiber synapse
(2018-03-12)The increase in the complexity of brains in evolution is accompanied by a surprisingly small number of new synaptic proteins, in particular when considering the remarkably wider range of behavioral responses a primate shows ... -
The Role of the E3 Ubiquitin Ligases Nedd4-1 and Nedd4-2 in Synaptic Transmission and Plasticity
(2013-05-28)Neurons are highly specialized cells that are connected at synapses to allow for the transfer of neuronal information. The development of synapses and the information processing and memory storage in mature synapses require ... -
The Role of the Ras Guanyl-Nucleotide Exchange Factor Rasgrp1 in Synaptic Transmission
(2010-10-22)Ras signaling pathways are known to regulate neuronal development and function. Ras G proteins have been implicated in the differentiation of neurons, e.g. in dendrite and dendritic spine ... -
Untersuchungen der Funktion des Kleinhirns mit Hilfe von Mausmutanten
(2011-01-17)Analysis of cerebellar function using mouse mutans- NDRF regulates differentiation and axon development of cerebellar basket cells -The cerebellar cortex is essentially comprised of three ...