Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Figura, Kurt von Prof. Dr. Dr. h.c."
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Ein Knockout-Mausmodell für Congenital Disorder of Glycosylation-IIc: Defizienz des Golgi-GDP-Fucose-Transporters
(2007-02-12)The monogenetic inherited human diseases termed 'Congenital Disorders of Glycosylation' (CDG) are caused by defects of enzymes and transporters involved in the modification of proteins by ... -
Molecular Characterization of pFGE, the Paralog of the C-α-Formylglycine-generating Enzyme
(2006-03-01)C-α formylglycine (FGly) is the catalytic residue in the active site of sulfatases. In eukaryotes, it is generated in the endoplasmic reticulum by post-translational modification of a ... -
Molecular mechanisms of the cytokine-dependent induction of the heme oxygenase-1 gene: in vivo and in vitro studies
(2004-09-27)Heme oxygenase 1 (HO-1) is the inducible enzyme which catalyzes the rate-limiting reaction of heme degradation yielding carbon monoxide (CO), divalent iron (Fe2+), and biliverdin. Due to a ... -
Regulation des mitochondrialen Zerfalls innerhalb der neuronalen Apoptose
(2007-05-23)Under physiological conditions, mitochondrial morphology dynamically shifts between a punctuate appearance and tubular networks by fission and fusion events. Mitochondrial apoptosis pathways ... -
Role of Adaptor Proteins in MPR sorting
(2003-06-04)Mannose 6-phosphate receptors mediate sorting of lysosomal enzymes and thus play an important role in lysosomal biogenesis. They bind to the mannose 6-phosphate residues on the lysosomal ... -
Signalbindung und Membraninteraktion von heterotetrameren Adaptorprotein-Komplexen
(2007-10-09)The heterotetrameric adaptor protein complexes AP1, AP2, AP3 and AP4 are involved in intracellular sorting of transmembrane proteins. APs interact with sorting signals of transmembrane ... -
TIP47 is recruited to lipid droplets and important for the organelle biogenesis and function
(2004-09-27)The cytoplasmic protein TIP47 (tail interacting protein of 47kD) was characterized as a cargo selection device for MPRs (mannose 6-phosphate receptors) and supposed to determine MPR transport ... -
σ1-adaptin - the Small Subunit of the Clathrin Adaptor Complex AP-1
(2005-06-03)The adaptor protein AP-1 is a heterotetrameric complex which mediates the formation of clathrin-coated vesicles at the trans-Golgi network and at endosomes. The interactions with ...