Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Heinrich, Ralf Prof. Dr."
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Funktionelle Analyse des Transkriptionsfaktors Pitx3 während der Entwicklung dopaminerger Neuronen im murinen Mittelhirn
(2013-09-04)The transcription factor PITX3 is expressed only in postmitotic mDA neurons of the midbrain and shows a complete co-expression of TH in the VTA and the SN. At a loss to PITX3 expression (aphakia mouse) the mDA neurons of ... -
Genetic Evidence For Neuron-Glia Metabolic Coupling In The CNS
(2016-07-27)The active contribution of oligodendrocytes and astrocytes to sustain brain physiology was completely underestimated, but severe consequences of their dysfunction in various diseases and glia-specific mutants emphasized ... -
Identification of Genes in the Dorsal Raphe Nucleus Regulated by Chronic Stress and Citalopram
(2006-06-16)It is known that stress, especially when it is chronic, can lead to mood disorders and changes in the serotonergic (5-HT) system, which most probably play a role in stress-induced ... -
Induktion und Spezifikation serotonerger Neurone des ventralen Rhombencephalon der Maus
(2009-10-26)The serotonergic (5-HT) system is involved in the modulation of mood and behaviour. Extrinsic factors, such as fibroblast growth factor 4 (Fgf4), Fgf8, and sonic hedghog (Shh), dictate ... -
Induktion von Apoptose in gynäkologischen Karzinomen <i>in vitro</i> und <i>in vivo</i> durch Antagonisten des Gonadotropin-Releasing Hormons Typ II
(2008-02-22)In human endometrial, ovarian and breast cancers, GnRH-I and GnRH-II and their receptors are parts of a negative autocrine regulatory system of cell proliferation. Based on a tumour-specific signal transduction, GnRH-I ... -
Involvement of N-type voltage dependent calcium channels in axon degeneration during experimental autoimmune optic neuritis
(2007-11-27)Optic neuritis is one of the most common clinical manifestations of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS). After an episode of optic ... -
Large Dense Core Vesicle Exocytosis in Mouse Chromaffin Cells is Regulated by Munc13s and Baiap3
(2008-12-16)Members of mammalian uncoordinated 13 protein family (Munc13s) are essential for SV exocytosis in neurons and have also been implicated in LDCV exocytosis in chromaffin cells. However, ... -
Maturation of GABAergic signaling during brainstem development
(2007-07-13)In the central nervous system, γ-aminobutyric acid (GABA) is known to act as an inhibitory neurotransmitter, via ligand-gated GABAA receptor channels and G protein-coupled GABAB receptors. ... -
Mechanisms underlying the functions of sleep in aging during starvation in Caenorhabditis elegans
(2019-09-12)Abstract: Sleep is vital for living organisms. Disruption of sleep is a hallmark of natural aging. A growing body of evidence suggests that sleep serves roles in nervous system-specific functions as well as general cell ... -
Modulation of Histone Deacetylases Attenuates the Pathogenesis of Alzheimer's disease
(2011-04-12)SummaryWe are yet to learn precisely how we learn. The molecular and physiological mechanisms that govern the process of cognition remain a mystery to scientific minds around the globe. ... -
Modulatorische Effekte von Stickstoffmonoxid und Juvenilhormon auf die Kontrolle des Reproduktionsverhaltens in weiblichen Chorthippus biguttulus
(2010-11-26)Juvenile hormone (JH) and nitric oxide (NO) both influence the reproductive behavior of female grasshoppers. The present thesis explores a possible connection between JH and NO signaling ... -
Molecular mechanism of Inhibition of the CREB-coactivator TORC by the mitogen-activated kinase DLK in pancreatic beta-cells
(2010-09-08)The ubiquitously expressed transcription factor CREB is involved in numerous cell signalling pathways including metabolic process, cell cycle or survival, cell growth and immune ... -
Molecular mechanisms of acute axonal degeneration in the rat optic nerve
(2015-12-03)The development of neuroprotective treatments is urgently needed for neurodegenerative and neurotraumatic diseases. As axonal degeneration is a key initiating event in these diseases, it is pivotal to better understand and ... -
Molecular mechanisms underlying cortical (mal)formation: case studies of ESCO2 and EXOSC10
(2021-09-23)This work focuses on elucidating the molecular mechanisms that control the cortical development. Identification of genes and factors that direct the development of the cerebral cortex will both tell us about their ... -
Multiplexed cell-based assays to profile GPCR activities and cellular signalling
(2016-03-23)G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors that are implicated in the physiological regulation of many biological processes. They mediate signals through complex networks of G ... -
Munc18 function in large dense-core vesicle exocytosis
(2005-03-23)Neurotransmitter and hormon release is based on Ca2+ dependent exocytosis. The sequential steps of exocytosis are executed by proteins and protein complexes. Formation of the SNARE complex ... -
Myelin lipids are energy reserves in the nervous system
(2021-03-18)Neuronal functions critically depend on a continuous supply of glucose as prolonged hypoglycemia can lead to severe brain injury. It is surprising that except for astroglial glycogen the brain has no visible energy reserves. ... -
Neuroendocrine effects of the endocrine disruptors Vinclozolin and Equol in the adult male rat
(2007-11-21)Numerous anthropogenic chemicals and natural plant-derived products can mimic or disrupt the normal function of endogenous sex steroid hormones by direct interaction with their specific nuclear receptors. These compounds ... -
Neuroligins Determine Synapse Maturation and Function
(2007-07-10)This project investigated the role of neuroligins in brainstem respiratory network of NL 1-3 and NL 2 conventional knockout mice. The deletion of all three neuroligin genes leaded to a ... -
Neuromuscular adaptations induced by long-term motor skill training
(2020-11-05)This thesis addresses the question of whether spinal cord’s monosynaptic circuitry can be altered due to long-term motor skill acquisition. We researched functional organization and skill-related adaptation in muscle spindle ...