Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Neher, Erwin Prof. Dr."
Now showing items 21-36 of 36
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Die Rolle der Synaptische Kurzzeitplastizität im neuronale Schaltkreise
(2010-12-03)Neuronal microcircuit is built by neurons connected with dynamic synapses. Short-term synaptic plasticity is one form of the synaptic dynamics, which plays various roles in the circuit ... -
SNARE assembly and regulation on membranes
(2006-08-01)The fusion of synaptic vesicles with the pre-synaptic plasma membrane is mediated by SNARE proteins. This work provides key insights into the behaviour of synaptobrevin, the SNARE protein ... -
SNAREs in evoked and spontaneous neurotransmission
(2010-02-04)The SNARE-complex consisting of synaptobrevin-2, SNAP-25, and syntaxin-1 is necessary for evoked synaptic transmission, but the involvement of the extended SNARE- bundle in different phases ... -
Spatial and temporal aspects of PI(4,5)P<sub>2</sub> and SNAREs in exocytosis studied using isolated membrane sheets and capacitance measurements
(2006-02-09)Ca2+-triggered exocytosis is a highly regulated process and the proteinaceous machinery mediating and regulating it has been studied in detail over the last decade. However, the participation ... -
Stoichiometric Biology of the Synapse
(2013-05-07)Synaptic transmission at chemical synapses relies on the fusion of neurotransmitter-loaded vesicles with the plasma membrane of the pre-synaptic terminal (exocytosis). The synaptic vesicle material is then retrieved from ... -
Structural/functional analysis of synaptotagmin 1 in synaptic transmission using hippocampal autapses
(2005-06-10)Synaptotagmin 1 is a presynaptic vesicular protein, which has been implicated as a putative Ca2+ sensor for fast neurotransmitter release in central nervous system. Structurally, it ... -
Study of synaptic vesicle cycling during exo- and endocytosis using optical approaches
(2012-09-25)In the central nervous system, communication between nerve cells mainly occurs at synapses via chemical neurotransmitters. Upon stimulation the transmitters are released by Ca2+-triggered exocytosis of synaptic vesicles ... -
Synaptic physiology of the developing <i>Drosophila</i> neuromuscular junction
(2007-04-25)There is a large increase in the number of synapses, and a constant structural and functional remodelling of already established synaptic sites, during the development of both the vertebrate ... -
Synaptic Targeting of Neurotransmitter Receptors is Regulated by Neurobeachin
(2011-11-14)In neuronal network, information is transferred mainly via chemical synapses. Typically, a neuron receives thousands of inputs, which are transmitted by the activation of a large number of ... -
Targeting gene therapy to neuroinfalmmatory lesions in experimental autoimmune encephalomyelitis
(2005-03-18)The blood-brain barrier (BBB) protects the central nervous system (CNS) from harmful substances but at the same time is an obstacle to therapy by blocking the transport of drugs into brain ... -
The establishment and characterization of an improved cell-free assay for exocytosis in neuroendocrine PC12 cells
(2005-11-04)Regulated exocytosis in neurons and neuroendocrine cells is mediated by the SNARE proteins synaptobrevin/VAMP, SNAP-25, and syntaxin 1. During fusion, these SNAREs form a stable complex ... -
The presynaptic protein Mover buffers synaptic plasticity at the hippocampal mossy fiber synapse
(2018-03-12)The increase in the complexity of brains in evolution is accompanied by a surprisingly small number of new synaptic proteins, in particular when considering the remarkably wider range of behavioral responses a primate shows ... -
The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse
(2006-10-23)We studied how afferent nerve activity affects the in-vivo maturation of a fast glutamatergic CNS synapse, the calyx of Held. To address this question we exploited the distinct ... -
The role of the presynaptic scaffold protein Bassoon in synaptic transmission at the mouse endbulb of Held synapse
(2013-06-20)Endbulbs of Held are large calyceal presynaptic terminals of auditory nerve fibers driving bushy cells in the AVCN. These synapses transmit precisely timed auditory signals up to high frequencies that provide the basis for ... -
Veranschaulichung subzellulärer physikalischer Kräfte biochemischen und mechanischen Ursprungs mittels FRET
(2005-12-09)The cellular cytoskeleton is composed of microfilaments, intermediate filaments, microtubules and a host of accessory proteins that control its dynamics during different, cell-type and ... -
Visualization of the Ca2+-dependent regulation of voltage-gated Ether-à-go-go channels by FRET microscopy
(2006-08-22)Several studies have suggested a role for EAG channels in the regulation of neuronal excitability, possibly by contributing to the maintenance of the resting membrane potential. EAG channels ...