Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Brose, Nils Prof. Dr."
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A neuronal PIP3-dependent program of oligodendrocyte precursor recruitment and myelination
(2017-01-26)Evolution of myelin has enabled rapid impulse propagation and development of complex brain circuitry. However, the in vivo mechanisms that trigger and orchestrate proliferation of oligodendrocyte precursor cells (OPCs), ... -
Analysis of Myelin Membrane Growth in Oligodendrocytes
(2015-12-07)Nervous systems of mammalian organisms are composed of various cell types with different morphology, function and connectivity. Understanding this complicity from a molecular point of view requires the application of ... -
Analysis of protein SUMOylation and its role in Alzheimer's disease using mouse models
(2017-04-26)Post-translational modifications serve as a cellular mechanism for the regulation of the activity, stability and localization of proteins. SUMOylation is a dynamic and reversible post-translational modification, which ... -
Biochemistry and physiological role of otoferlin
(2011-11-24)In humans deafness is caused by environmental but also by genetic factors. Mutations in the gene encoding otoferlin are one genetic cause of deafness, leading to DFNB9 an autosomal recessive ... -
Cellular Prion Protein (PrPC): Identification and Characterization of Novel Interacting Partners
(2011-12-07)The cellular prion protein (PrPC) is highly conserved throughout the evolution of mammals. (What does this sentence mean? What do you mean by ``conserved´´? This protein was higly conserved ... -
Characterization of Synaptic Transmission Abnormalities in Neurological Disorders of the Presynaptic Terminal
(2022-03-04)Seminal methodological advancements in the field of human genetics now allow for low-cost sequencing of complete coding genomes, and rich sources of corresponding data now exist for healthy and patient cohorts, allowing ... -
Characterizing the SUMOylation of APC4 and the Function of APC4 Within Neurons
(2021-09-23)The Anaphase Promoting Complex (APC/C) is an E3 ubiquitin ligase that is involved in multiple molecular processes in eukaryotic cells. It is regulated by an intricate system of post-translational modifications that enables ... -
Charakterisierung der Proteinphosphatase 1E (PPM1E) - Lokalisierung und Trunkation in Gehirngewebe und Effekte auf neuronale Morphologie in primärer Neuronenkultur
(2010-11-26)Alzheimer s disease (AD) is a progressive neurodegenerative disorder, characterized by early deficits in learning and memory with eventual loss of higher cognitive functions. Although ... -
Conformational state of monomeric kinesin UNC-104
(2012-11-06)The fast anterograde monomeric kinesin-3 motor UNC-104 is crucial for synaptic vesicle transport in neurons. in vitro, UNC-104 is a non-processive motor with biased-diffusional motion behaviour on a single molecule level. ... -
Dynamic expression of Mover in rodent endbulbs of Held
(2016-05-12)The central auditory pathway contains highly specialized giant presynaptic nerve terminals specialized to preserve temporal information carried by acoustic signals (Oertel et al., 1999). One of them, the endbulbs of Held, ... -
Effects of anle138b treatment on amyloid-β neurotoxicity
(2020-10-02)Alzheimer’s disease (AD), the leading etiology of dementia and the fifth cause of death worldwide, has been declared a public health priority by the World Health Organization in 2017. AD is incurable and no treatment can ... -
Expression and function of PSD-93 isoforms in hippocampal synapses
(2010-08-11)Changes in the strength of synaptic transmission are thought to underlie information processing in the brain. At excitatory synapses in the hippocampus, synaptic strength is determined by ... -
Functional organisation of the central complex of the grasshopper <i>Chorthippus biguttulus</i> in relation to sound production
(2008-05-27)The central complex is a major control neuropile for the situation specific selection of sound pattern of grasshoppers. The current thesis tries to investigate the role of different neurotransmitter systems in this brain ... -
Glutamate receptors potentiate single K-ATP channels through intracellular ATP changes
(2013-12-20)Rett Syndrome (RTT) is a neurodevelopmental disorder caused primarily by mutations in a Mecp2 gene and exclusively affects females. RTT is one of the prevalent developmental disorders with a high frequency of occurrence ... -
Identification of Genes in the Dorsal Raphe Nucleus Regulated by Chronic Stress and Citalopram
(2006-06-16)It is known that stress, especially when it is chronic, can lead to mood disorders and changes in the serotonergic (5-HT) system, which most probably play a role in stress-induced ... -
Investigation of early endosomal sorting and budding
(2009-11-04)Early endosomes constitute a major sorting platform of eukaryotic cells. They receive endocytic carrier vesicles from the plasma membrane and trafficking vesicles from the Golgi complex and ... -
Isolation and characterisation of synaptic vesicles from mouse brain
(2011-08-08)All eukaryotic cells exhibit a constant turnover of membrane components via trafficking of vesicles between subcellular compartments. A classical example of a dynamic membrane delimited ... -
Mechanisms underlying the functions of sleep in aging during starvation in Caenorhabditis elegans
(2019-09-12)Abstract: Sleep is vital for living organisms. Disruption of sleep is a hallmark of natural aging. A growing body of evidence suggests that sleep serves roles in nervous system-specific functions as well as general cell ... -
Myokardinfarktregeneration unter Verwendung kardiovaskulärer Vorläuferzellen aus murinen und humanen pluripotenten Stammzellen
(2013-02-19)Stem cells hold a great promise in regenerative therapies for cardiovascular diseases. Heart regeneration with stem cells requires a delicate balance between the loss of donor cell pluripotency (so that teratoma formation ... -
Neuroprotektion und Neurorestauration im MPTP Modell der Parkinson Erkrankung
(2010-07-01)Parkinson s disease (PD) is the most common neurodegenerative movement disorder of the basal ganglia and is characterized by a progressive loss of dopaminergic neurons in the substantia ...