Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Fischer, André Prof. Dr."
Now showing items 1-10 of 10
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The roles of long non-coding RNAs in CNS diseases with a focus on astroglial-neuronal communication
(2025-02-14)Aging is accompanied by a decline of cognitive functions and represents a major risk factor for the development of neurodegenerative diseases such as Alzheimer’s disease (AD). Key pathological changes linked to AD are the ... -
Investigating myelination in human bioengineered neuronal organoids (BENOs)
(2024-05-21)Myelination is a critical process for the optimal functioning of both the central and peripheral nervous systems. It involves wrapping nerve fibers with a myelin sheath to ensure the swift transmission of electrical signals, ... -
The role of RNA in synapse physiology and neurodegeneration in models of Parkinson’s disease
(2022-06-14)Synaptic dysfunction is an early alteration in multiple neurodegenerative disorders. Parkinson’s disease (PD) is characterised by the accumulation of α-synuclein (αsyn) in pathological inclusions known as Lewy bodies ... -
Molecular mechanisms underlying cortical (mal)formation: case studies of ESCO2 and EXOSC10
(2021-09-23)This work focuses on elucidating the molecular mechanisms that control the cortical development. Identification of genes and factors that direct the development of the cerebral cortex will both tell us about their ... -
Loss of Setd1b methyltransferase in the murine forebrain as a novel model for human intellectual disability
(2020-12-22)Methylation of histone 3 lysine 4 (H3K4me3) is an epigenetic mark for active transcription, which is mediated in mammals by six enzymes of the SET1/MLL family of histone methyltransferases (KMTs). All of them have been ... -
Untersuchungen zu den selbst-replizierenden Eigenschaften des pathogenen Prion-Proteins beim Menschen
(2016-02-11)Prion diseases are transmissible, fatal neurodegenerative diseases of humans and animals. They are linked to the conversion of the cellular prion protein (PrPC) into its pathogenic form (PrPSc). Due to this conversion prion ... -
Role of myelin-associated NAD+- dependent deacetylase Sirtuin 2 in modifying axonal degeneration
(2013-01-25)In the central nervous system (CNS), oligodendrocytes (OLs) ensheath axons with lipid-rich myelin membranes that provide an electrical insulation and are essential for fast nerve impulse transmission. However, myelination ... -
Cocaine-inducible circuitry reorganization as a basis for addiction-related memory traces
(2013-01-16)Drug addiction has been conceptualized as an extreme, pathological form of memory. One potential mechanism underlying addiction-related memories is drug-induced plastic changes at glutamatergic synapses within the brain ... -
A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia
(2012-12-07)Summary A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia Schizophrenia (SZ) is as severe and phenotypically as well ... -
Modulation of Histone Deacetylases Attenuates the Pathogenesis of Alzheimer's disease
(2011-04-12)SummaryWe are yet to learn precisely how we learn. The molecular and physiological mechanisms that govern the process of cognition remain a mystery to scientific minds around the globe. ...