Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Göpfert, Martin Prof. Dr."
Now showing items 1-20 of 27
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Molecular Mechanisms of Frequency Discrimination in the Drosophila Ear
(2023-01-24)Since the first confirmed evidence of potassium ions crossing the membrane to the first cloned and identified potassium channel from Drosophila melanogaster, the studies of potassium channels have extensively broadened our ... -
Regulation of mechanical feedback amplification in the Drosophila ear
(2022-06-09)Ears achieve their exquisite sensitivity using positive mechanical feedback (Ashmore et al., 2010). Like pushing a swing augments its swing, sound-induced vibrations are enhanced by motile responses of auditory receptor ... -
Molecular role of PMP22 in CMT1A
(2021-07-02)Myelinating Schwann cells wrap around peripheral axons and allow fast neural transmission. Peripheral myelin protein of 22 kDa (PMP22) is a transmembrane protein strongly expressed in Schwann cells. Alterations in PMP22 ... -
Myelin lipids are energy reserves in the nervous system
(2021-03-18)Neuronal functions critically depend on a continuous supply of glucose as prolonged hypoglycemia can lead to severe brain injury. It is surprising that except for astroglial glycogen the brain has no visible energy reserves. ... -
Vimentin protects differentiating stem cells from stress
(2020-12-10)Vimentin is the first cytoplasmic intermediate filament to be expressed in mammalian cells during early differentiation, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in ... -
Behavioual Adaptations to Light Deprivation
(2019-03-20)Similar to most non-sedentary animals, Drosophila shows a wide range of visually guided behaviours and their functionality is crucial for survival. Previous studies showed that visual impairment significantly reduced the ... -
Identification and Characterization of Protein Complexes Involved in Different Pain States in Vertebrates
(2019-02-28)Chronic pain imposes substantial challenges to medical practice as the treatment options for its clinically relevant manifestations are limited. Owing to lack of knowledge about the exact molecular mechanism underlying ... -
Chromophore-independent roles of Drosophila opsin apoproteins and visual cycle components
(2019-02-13)Visual rhodopsins consist of opsin protein moieties that are covalently bound to 11-cis-retinal, the visual chromophore that is derived from vitamin A. In Drosophila, the visual opsin genes Rh5 and Rh6 were reported to be ... -
Characterization of protein complexes associated with TRP channels in the context of nociception
(2017-12-05)The transient receptor potential A1 (TRPA1) channel is essential for vertebrate pain. TRPA1 plays a fundamental role as a primary detector of noxious stimuli of physical and chemical nature, and is critically involved in ... -
Encoding, coordination, and decision making in the primate fronto-parietal grasping network
(2017-09-22)The processes taking place in our brain allow us to flexibly interact with our surrounding based on our internal demands. This requires perceptual information processing up to the generation of movements taking place in ... -
Morphological Analysis of Kenyon Cells of the Drosophila Mushroom Bodies
(2017-01-18)Learning and memory is an adaptive behavioral trait that allows animals to make predictions about their environment based on previous experiences. Fruit flies that commonly use olfactory cues to locate food sources or ... -
Multiplexed cell-based assays to profile GPCR activities and cellular signalling
(2016-03-23)G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors that are implicated in the physiological regulation of many biological processes. They mediate signals through complex networks of G ... -
Modulation of the ROCK pathway in models of Parkinson´s disease
(2015-12-09)The cure of neurodegenerative diseases is one of the main goals in today’s neuroscience research. One of the main obstacles is the delayed diagnostics in relation to molecular pathology. In Parkinson’s disease (PD), several ... -
Charakterisierung und experimentelle Therapien eines neuen Mausmodells für das Rett Syndrom
(2015-11-20)Rett syndrome is one of the most frequent genetic causes of mental retardation of females. To date still no treatment exists for this disease, although genetic approaches in mice showed that Rett syndrome is treatable, at ... -
Analyses of improved long term memory in SHARP1 and SHARP2 double knockout mice
(2015-09-15)The transition of recent experiences into stable and remote memory traces is an important task that mainly occurs during sleep. Sleep-associated consolidation of remote long-term memory is based on cortical networks that ... -
Functional Analysis of Two Major Sperm Tail Proteins Identifies ODF1 as Being Essential for the Tight Linkage of the Sperm Head to the Tail via SPAG4 and ODF2 as A Component of the β-catenin Destruction Complex
(2015-04-02)In the mammalian sperm tail, the outer dense fibers (ODFs) are accessory fibers accompanying the axonemal tubuli doublets on their outer site. The ODFs are composed of at least 14 polypeptides of which only a few have been ... -
Der Einfluss von Neuregulin-1 auf Erkrankungen des peripheren Nervensystems
(2014-07-08)A duplication of the gene encoding the peripheral myelin protein 22kDa (PMP22) underlies the commonest inherited neuropathy, Charcot Marie Tooth disease 1A (CMT1A). Although demyelination is a characteristic disease feature, ... -
Glutamate receptors potentiate single K-ATP channels through intracellular ATP changes
(2013-12-20)Rett Syndrome (RTT) is a neurodevelopmental disorder caused primarily by mutations in a Mecp2 gene and exclusively affects females. RTT is one of the prevalent developmental disorders with a high frequency of occurrence ... -
Neuronale Grundlagen appetitiven und konsumatorischen Verhaltens: Die Funktion des Neuropeptids SIFamid bei Drosophila melanogaster
(2013-09-18)Feeding behavior is crucial for survival of animals and a partial aspect of a homeostatic process. Appetitive and consumption behavior are induced by innate and motivational conditions. Satiated and unsatiated states depend ... -
A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia
(2012-12-07)Summary A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia Schizophrenia (SZ) is as severe and phenotypically as well ...