Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Groß, Uwe Prof. Dr."
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DNA methylation as a potential epigenetic driver of morphological development in Candida albicans
(2022-01-04)Candida albicans is a commensal yeast in the mammalian gut, but also has retained its virulence potential while co-evolving in mammalian species. As a perfectly adapted opportunist colonizing mucosal surfaces, it is also ... -
Variability of biofilm formation in Candida glabrata and Candida parapsilosis and its consequences on the infection process
(2019-08-30)The prevalence of Candida species has increased in the last two decades, becoming the third to fourth most common cause of infections in hospitals. In general, Candida spp. are opportunistic pathogens found as commensals ... -
Characterization of genes differentially regulated after bile acid exposure in Campylobacter jejuni
(2019-08-23)In the past decades Campylobacter has raised as the main cause of bacterial gastrointestinal infection worldwide. Campylobacter causes gastrointestinal infection that can vary from asymptomatic, mild to a severe diarrhea. ... -
Impact of Toxoplasma gondii on STAT1 activity and epigenetic regulation during IFN-γ signaling of its host cell
(2018-08-21)Toxoplasma gondii is an obligate intracellular parasite which infects up to 30% of humans world-wide. To control T. gondii, the host mounts a strong IFN-γ-driven immune response via the signal transducer and activator of ... -
Regulation of Toxoplasma gondii bradyzoite differentiation in terminally differentiated skeletal muscle cells
(2017-11-28)Toxoplasma gondii is an intracellular protozoan parasite that infects warm-blooded animals including an estimated thirty percent of humans world-wide. In immunocompetent host, primary infection is usually asymptomatic but ... -
Oxidative stress pathways in the pathogenesis of renal fibrosis
(2016-05-23)In the pathogenesis of renal fibrosis, oxidative stress (OS) enhances the production of reactive oxygen species (ROS) leading to sustained cell growth, inflammation, excessive tissue remodelling and accumulation, which ... -
Untersuchungen zu den selbst-replizierenden Eigenschaften des pathogenen Prion-Proteins beim Menschen
(2016-02-11)Prion diseases are transmissible, fatal neurodegenerative diseases of humans and animals. They are linked to the conversion of the cellular prion protein (PrPC) into its pathogenic form (PrPSc). Due to this conversion prion ... -
Identifizierung neuer Coregulatoren von SOX9 und RUNX2 in chondrogenen Progenitorzellen in der Osteoarthrose
(2015-06-23)Osteoarthritis is a degenerative disease of the joints. It is characterized by a successive destruction of the articular cartilage and surrounding structures. Osteoarthritis is the most common musculoskeletal joint disease ... -
Identifizierung schutzvermittelnder Antigene von Aspergillus fumigatus für eine Impfstoffentwicklung zur Verhütung invasiver Aspergillosen bei Leukämie-Patienten
(2015-01-23)A.fumigatus is the most common cause of invasive, usually fatal aspergillosis in severely immunocompromised patients. A natural resistance to the fungus is mediated by the innate immune system. Additionally, an acquired ... -
Entwicklung von diagnostischen Methoden zum Nachweis von europäischen humanpathogenen Arboviren
(2014-10-17)A majority 50-70% of aseptic meningo-encephalitis cases is caused by unknown aetiological agents.
In the course of this work a cytometric bead array (CBA) for simultaneous detection of antibodies against ...
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Zelltyp-spezifische Interaktionen von Toxoplasma gondii und murinen Skelettmuskelzellen in vitro
(2014-06-26)Toxoplasma gondii is one of the most common intracellular protozoan parasites worldwide and an important human pathogen. Its life cycle includes three stages: sporozoites, tachyzoites and bradyzoites. While sporozoites are ... -
Human and mouse meniscus progenitor cells and their role in meniscus tissue regeneration
(2014-05-19)Osteoarthritis (OA) is a degenerative disease of hyaline cartilage. The cartilage is an avascular tissue, once damaged it is difficult to repair. Articular cartilage is responsible for the smooth, frictionless, and painless ... -
Identifizierung und Charakterisierung der Dihydroorotat Dehydrogenase als Zielstruktur von 1-Hydroxyquinolonen in Toxoplasma gondii
(2014-01-06)1-Hydroxyquinolones were recently described as effective inhibitors of Toxoplasma gondii replication. These compounds (e.g. HDQ and compound B) were previously shown to inhibit the alternative NADH dehydrogenase (NADH2-I) ... -
Investigating the role of lipocalin-2 as a diagnostic indicator for nonalcoholic steatohepatitis in a fructose-induced rat fatty liver model: First experimental studies
(2013-12-17)The liver is the vital organ for fat and carbohydrate metabolism as well as detoxification and excretion of metabolites. Any functional impairment will thus affect the whole organism and is absolutely undesirable. Nonalcoholic ... -
Characterization of the cell wall protein Ecm33 family in Candida glabrata
(2013-09-05)Candida glabrata is the second most frequent cause of local and systemic human candidiasis and infections with this species are difficult to treat because of frequent azole resistance. C. glabrata infections have high ... -
Molecular and Functional Characterization of Programmed Cell Death (PCD) in Toxoplasma gondii
(2013-05-06)Toxoplasma gondii is a protozoan parasite which leads to widespread infections in humans and animals worldwide. Infection is typically asymptomatic in immunocompetent hosts, but may lead to severe symptoms in immunocompromized ... -
Hemmung der Cytochrom c-induzierten Caspase-Aktivierung durch Toxoplasma gondii in vitro und in vivo:molekulare Mechanismen und parasitäre Effektormoleküle
(2012-11-22)Toxoplasma gondii is an obligate intracellular parasite and is able to infect almost all nucleated cells of humans and warm-blooded animals. Infection of immunocompetent individuals is mostly asymptomatic and leads to ... -
Serum Lipocalin-2 (LCN-2) as a major acute phase protein under different pathological conditions in vivo and in vitro studies
(2012-02-28)Lipocalin-2 (LCN-2) is a pleiotropic 25-kDa secretory protein, currently used as a biomarker for renal injury and inflammation. Its serum level is increased under different pathological ... -
Epidemiologische Untersuchungen zur Toxoplasmose und Identifizierung immunogener parasitärer Antigene
(2012-02-23)Toxoplasmosis is an infectious disease caused by the parasite Toxoplasma gondii. Whereas the infection proceeds in most cases asymptomatically in immunocompetent humans, a threat for the ... -
Proteomic investigation of the molecular targets of mycophenolic acid in human cells
(2012-02-14)Mycophenolic acid (MPA) is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key regulator of purine biosynthesis. MPA is frequently used as an immunosuppressant drug to ...