Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Heinrich, Ralf Prof. Dr."
Now showing items 1-20 of 57
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Anti-apoptotic and neuroprotective erythropoietin/CRLF3-signalling in insects and humans
(2022-06-14)The cytokine receptor like factor 3 (CRLF3) evolved together with the eumetazoan nervous system and is present in all major groups of Animalia. Based on sequence similarities, CRLF3 was assigned to the family of class 1 ... -
Molecular mechanisms underlying cortical (mal)formation: case studies of ESCO2 and EXOSC10
(2021-09-23)This work focuses on elucidating the molecular mechanisms that control the cortical development. Identification of genes and factors that direct the development of the cerebral cortex will both tell us about their ... -
Schwann cells restrict axonal diameters via CMTM6
(2021-05-03)Myelination of axons accelerates nerve impulse propagation 20-100-fold, theoretically allowing rapid nerve conduction with reduced axonal diameters. However, to our knowledge no myelin dependent signal has been described ... -
Myelin lipids are energy reserves in the nervous system
(2021-03-18)Neuronal functions critically depend on a continuous supply of glucose as prolonged hypoglycemia can lead to severe brain injury. It is surprising that except for astroglial glycogen the brain has no visible energy reserves. ... -
Development of Transgenic Sterile Insect Technique Strains for the Invasive Fruit Pest Drosophila suzukii
(2020-12-03)Globalization has contributed enormously to emergence and expansion of invasive pests. A recent example is the invasion in Europe and the USA by the cherry vinegar fly Drosophila suzukii. The pest has high potential to ... -
Neuromuscular adaptations induced by long-term motor skill training
(2020-11-05)This thesis addresses the question of whether spinal cord’s monosynaptic circuitry can be altered due to long-term motor skill acquisition. We researched functional organization and skill-related adaptation in muscle spindle ... -
Functional characterization and molecular identification of neuroprotective receptors for erythropoietin-like ligands
(2019-12-19)The cytokine erythropoietin (Epo) regulates erythropoiesis but also protects mammalian neurons from apoptosis. However, receptors and transduction pathways involved in neuroprotection are only partially characterized. ... -
Mechanisms underlying the functions of sleep in aging during starvation in Caenorhabditis elegans
(2019-09-12)Abstract: Sleep is vital for living organisms. Disruption of sleep is a hallmark of natural aging. A growing body of evidence suggests that sleep serves roles in nervous system-specific functions as well as general cell ... -
Behavioual Adaptations to Light Deprivation
(2019-03-20)Similar to most non-sedentary animals, Drosophila shows a wide range of visually guided behaviours and their functionality is crucial for survival. Previous studies showed that visual impairment significantly reduced the ... -
Olfactory neurogenesis during tissue maintenance and repair
(2018-06-12)During metamorphosis, the African clawed frog Xenopus laevis undergoes a fundamental transformation from a fully aquatic larva to a secondarily aquatic adult. This extensive habitat change requires major adaptations including ... -
Attention shift and remapping across saccades
(2017-03-15)Humans and monkeys make two to three saccades per second on average when they are awake, and they are able to keep track of relevant visual stimuli while making saccadic eye-movements to scan a visual scene. Since the ... -
A neuronal PIP3-dependent program of oligodendrocyte precursor recruitment and myelination
(2017-01-26)Evolution of myelin has enabled rapid impulse propagation and development of complex brain circuitry. However, the in vivo mechanisms that trigger and orchestrate proliferation of oligodendrocyte precursor cells (OPCs), ... -
TRPV1 regulates excitatory innervation of oriens lacunosum moleculare (OLM) neurons in the hippocampus to affect synaptic plasticity
(2017-01-11)The transient receptor potential vanilloid channel 1 (TRPV1) is a non-selective ion channel capable of being activated by multiple factors such as noxious stimuli, heat (>42 °C), low pH and pungent agents. Due to its pivotal ... -
Erythropoietin-mediated neuroprotection in insects
(2016-08-30)The cytokine erythropoietin (Epo) initiates adaptive cellular responses to a variety of mechanical and physiological insults in various non-hematopoietic mammalian tissues including the nervous system. Previous studies on ... -
Genetic Evidence For Neuron-Glia Metabolic Coupling In The CNS
(2016-07-27)The active contribution of oligodendrocytes and astrocytes to sustain brain physiology was completely underestimated, but severe consequences of their dysfunction in various diseases and glia-specific mutants emphasized ... -
Amyloid-beta driven changes in transcriptome plasticity: From OMICS to Therapy
(2016-04-06)Alzheimer’s disease is characterized by a progressive cognitive decline coinciding with the formation of amyloid plaques and tau fibrils in the human brain. It is the most common form of dementia and the number of people ... -
Multiplexed cell-based assays to profile GPCR activities and cellular signalling
(2016-03-23)G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors that are implicated in the physiological regulation of many biological processes. They mediate signals through complex networks of G ... -
Molecular mechanisms of acute axonal degeneration in the rat optic nerve
(2015-12-03)The development of neuroprotective treatments is urgently needed for neurodegenerative and neurotraumatic diseases. As axonal degeneration is a key initiating event in these diseases, it is pivotal to better understand and ... -
Analyzing UNC-50/GMH1 dependent membrane trafficking in yeast and C. elegans
(2015-11-30)Although the basic principles of the intracellular trafficking of proteins and lipids within the secretory apparatus have been established, the precise regulation of molecular membrane transport events is still not well ... -
Funktionelle Analyse des Transkriptionsfaktors Pitx3 während der Entwicklung dopaminerger Neuronen im murinen Mittelhirn
(2013-09-04)The transcription factor PITX3 is expressed only in postmitotic mDA neurons of the midbrain and shows a complete co-expression of TH in the VTA and the SN. At a loss to PITX3 expression (aphakia mouse) the mDA neurons of ...