Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Kehlenbach, Ralph Prof. Dr."
Now showing items 1-8 of 8
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Characterization of human Neuropsin (hOPN5) and development of new mutants for optogenetic stimulation of the Gq signaling cascade
(2024-02-20)Gq signaling plays a pivotal role in the physiological adaptation of cellular behavior based on the individual body's needs and it is also involved in the pathogenesis of many diseases including cancer, autoimmunity, ... -
Is increased Na+ influx a cause of mitochondrial redox stress, cardiomyopathy, and a therapeutic target?
(2023-11-09)Maintaining balanced Na+ levels is critical for normal functioning of cardiomyocytes, including contractions, excitation-contraction coupling (ECC), and metabolism. The NaV1.5-F1759A (human) mutation, which increases ... -
Investigation of the structure of spliceosomal complexes from the yeast S. cerevisiae
(2021-03-19)Nuclear pre-mRNA splicing is catalysed by the spliceosome, a multi-megadalton ribonucleoprotein (RNP) complex. It assembles de novo for each round of splicing on premRNA intron with stepwise binding of five small nuclear ... -
Etablierung eines Nachweisverfahrens zur Untersuchung der räumlichen und zeitlichen Verteilung mitochondrial translatierter Proteine mit hochauflösender STED-Mikroskopie durch metabolische Markierung mit nicht-kanonischen Aminosäuren
(2017-09-14)Metabolic labeling of nascent polypeptides using non-canonical amino acids is a valuable tool enabling researchers to introduce bioorthogonal functional groups into proteins. These can subsequentially be used for identifying ... -
The prostaglandin 15-deoxy- Δ12,14 -PGJ2 inhibits CRM1 mediated protein export. Analysis of nuclear import of human telomerase reverse transcriptase
(2014-02-07)Nuclear import and export of macromoloecules are essential processes in eukaryotic cells. In consequence, different mechanisms of transport developed in the cell, resulting in the involvement of different monodirectional ... -
Regulation of Dual Leucine Zipper Kinase (DLK) by Prediabetic Signals
(2013-11-01)Diabetes mellitus type 2 is the most increasing metabolic disease worldwide. The disease is recognized by the disability of endocrine pancreas to afford the high metabolic demand which has been raised due to insulin ... -
Analysis of CRM1- and Nup214- dependent nuclear export of proteins
(2012-12-12)Nuclear pore complexes (NPCs) are giant units of the nuclear envelope, mediating directional transport into and out of the nucleus. Nucleoporins are the main components of the NPC, and one third of them contain ... -
Control of E-cadherin Function in Cell Intercalation by ER Glucosylation Enzymes
(2012-11-05)Three consecutive glucosylations are the last steps in formation of the dolichol-PP-glycans before the glycans are transferred to nascent proteins in the ER. These three glucosyl residues are assumed to function in protein ...