Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Melchior, Frauke Prof. Dr."
Now showing items 1-9 of 9
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Regulation of Kinesin-3 activity by active zone protein SYD-2
(2011-12-12)This work focusses on characterizing the effect of SYD-2/kinesin interaction on the motility and mechanochemical properties of UNC-104 motor. The motility properties of molecular motors can ... -
Mass Spectrometric Analyses of Post-Translationally Modified Proteins
(2011-01-05)Protein post-translational modifications (PTMs) possess key functions in the regulation of various cellular processes. In this thesis, several new technologies are developed to map protein ... -
Molecular mechanism of Inhibition of the CREB-coactivator TORC by the mitogen-activated kinase DLK in pancreatic beta-cells
(2010-09-08)The ubiquitously expressed transcription factor CREB is involved in numerous cell signalling pathways including metabolic process, cell cycle or survival, cell growth and immune ... -
Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)
(2010-01-21)The prolyl-4 hydroxylase domain enzymes 1-3 (PHD1-3) are involved in regulating the protein stability of the alpha subunit of the hypoxia inducible factor (HIF), which is the master regulator ... -
Zellbiologische Untersuchung α-Mannosidase-defizienter und Enzym-behandelter Mäuse
(2009-11-04)The deficiency of the lysosomal α-mannosidase leads to the lysosomal storage disease α-mannosidosis. A feasible option for the treatment of this disease is the substitution of the missing ... -
A new rodent model of Parkinson s Disease based on neuron specific downregulation of glutathione production.
(2009-04-21)Parkinson s disease (PD) is characterized by a progressive degeneration of the nigrostriatal system. Only in few patients genetic mutations have been identified to cause disease onset, ... -
Characterizing the RanGAP1-RanBP2 complex in mitosis
(2009-03-18)The RanGAP1-RanBP2 complex represents a fascinating macromolecular assembly comprising at least two enzymatic activities. On one hand, it harbors the GTP hydrolysis activating function of ... -
SUMOylierung von NFYA
(2009-02-13)Reversible post-translational modification with SUMO (small ubiquitin-related modifier) is an important mechanism to regulate the function, activity or localization of target proteins. ... -
„Ex vivo” Replikation des pathogenen Prion Proteins
(2007-01-29)The prion protein (PrP) is an ubiquitous protein. Prion stands for proteinaceous infectious particle and is according to the 'protein-only hypothesis' the infective agens of the transmissible ...