Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Pöggeler, Stefanie Prof. Dr."
Now showing items 1-20 of 41
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A novel rRNA quality control function for Npl3 in Saccharomyces cerevisiae
(2024-03-25)In all domains of life, ribosomes are essential complexes that are the sole source for protein synthesis. Ribosome biosynthesis, the most energy-consuming process in a cell, has to be tightly regulated. Misregulation ... -
The complex formation of RNase P and RNase MRP in Saccharomyces cerevisiae
(2024-03-06)Ribonucleoproteins comprise a class of complexes that consist of RNAs and proteins. Riobozymes are catalytically active ribonucleoproteins that play a key role in the maturation of various RNAs. A prominent example is ... -
Characterization of Npl3 as a 5'- and 3'- quality control factor
(2023-09-11)Maturation of RNA polymerase II transcripts consists of 5’-capping, splicing, cleavage and 3’-polyadenylation. These processes can generate faulty transcripts that have to be retained in the nucleus to be degraded. An mRNA ... -
Morphological and molecular adaptation of Aspergillus niger to simulated spaceflight and Mars-like conditions
(2021-10-18)The International Space Station (ISS) is an indoor-closed environment in Low Earth Orbit (LEO). Outside of the ISS, radiation is the most challenging factor outside. In turn, inside the ISS, spaceflight microgravity is the ... -
Assessment of antibiotic resistance in soil and its link to different land use types and intensities
(2020-07-15)Nowadays, bacterial infections pose a serious risk for human health again, due to multi-resistant pathogens insensitive to antibiotic treatment. Some of the antibiotic resistance genes (ARGs) carried by these pathogens ... -
Metagenomics in One Health — from standardization to targeted application
(2020-04-21)This thesis is meant to further the applicability of metagenomics in One Health by discussing key forms of standardization, as well as targeted applications. Metagenomics is a powerful pathogen-agnostic tool, allowing for ... -
Taxonomic and Functional Characterization of Biopolymer-degrading Microbial Communities in the Intestinal Tract of Beavers
(2019-05-09)The mammalian gut harbors a complex and specialized microbiota, which includes all tree domains of life (Archaea, Bacteria, and Eukarya). Bacteria are the most abundant group within the gut system, and they take part in ... -
Phylogenetic and functional diversity of soil prokaryotic communities in temperate deciduous forests with different tree species
(2019-04-30)Forest ecosystems provide an important contribution to global carbon storage through processes mediated by trees. As the dominant forest vegetation, trees largely drive primary productivity and mediate the flow of aboveground ... -
Verticillium dahliae transcription factors Som1 and Vta3 control microsclerotia formation and sequential steps of plant root penetration and colonisation to induce disease
(2018-10-12)Verticillium dahliae belongs to the soil-borne ascomycete fungi. It causes wilt diseases and early senescence in more than 200 plant species including economically important crops. It can exist in the soil without a host ... -
Localization and Function of RNases in Bacillus subtilis
(2017-03-29)The ability to adapt to changing environmental conditions is essential for every organism to survive. In bacteria, this adaptation relies on the control of the mRNA synthesis, stability, and turnover, which allows the ... -
Analyse der UPR vermittelten Stressantwort und ihrer Funktion während der biotrophen Entwicklung von<i> Ustilago maydis</i>
(2016-12-09)The unfolded protein response (UPR) is a conserved eukaryotic signaling network that is activated by accumulation of misfolded proteins in the endoplasmic reticulum (ER) to ensure protein homeostasis. In the baker's yeast ... -
Stress Response SCF Ubiquitin Ligase F box Protein Fbx15 Controls Nuclear Co repressor Localization and Virulence of the Opportunistic Human Fungal Pathogen Aspergillus fumigatus
(2016-09-06)Aspergillus fumigatus is the most prevalent cause for pulmonary infections in immuno-compromised patients. Virulence factors are often linked to developmental control mechanisms, which are often identified in the closely ... -
Phosphorylation dependent stability control of the deneddylase DenA and its impact on Aspergillus nidulans development
(2016-04-05)Summary Malfunctioning protein degradation in higher eukaryotes is associated with numerous diseases, including neurodegenerative disorders and cancer. Understanding regulation mechanisms of protein degradation is thus ... -
Comparative DNA‐Protein Interaction and Epithelial Tight Junctions Modulation Potential of Immunosuppressive Regime
(2016-01-28)Mycophenolic acid (MPA) is an important immunosuppressive drug (ISD) prescribed to prevent graft rejection in the organ transplanted patients. However, its use is sporadically linked to the leak flux diarrhea and other ... -
Diversity and Ecology of the Roseobacter Clade and other Marine Microbes as revealed by Metagenomic and Metatranscriptomic Approaches
(2015-05-29)Marine Bacteria and Archaea represent the major part of the total biodiversity on Earth. They are main drivers of biogeochemical cycles in marine environments and play an integral role in ecosystem structuring. Therefore, ... -
Analyses of the Life Cycle of TLC1 and the Nuclear RNA Quality Control System in Saccharomyces cerevisiae
(2015-04-24)During genome replication, chromosomes undergo a progressive shortening of their ends. To counteract this loss, a complex named telomerase functions as a reverse transcriptase to elongate telomeres. In Saccharomyces ... -
Identifizierung schutzvermittelnder Antigene von Aspergillus fumigatus für eine Impfstoffentwicklung zur Verhütung invasiver Aspergillosen bei Leukämie-Patienten
(2015-01-23)A.fumigatus is the most common cause of invasive, usually fatal aspergillosis in severely immunocompromised patients. A natural resistance to the fungus is mediated by the innate immune system. Additionally, an acquired ... -
GlmY and GlmZ: a hierarchically acting cascade composed of two small RNAs
(2014-09-10)In Escherichia coli and other enterobacteria, the homologous small RNAs (sRNAs) GlmY and GlmZ act in a hierarchical manner to feedback control expression of key enzyme glucosamine-6-phosphate (GlcN6P) synthase GlmS. Enzyme ... -
Zelltyp-spezifische Interaktionen von Toxoplasma gondii und murinen Skelettmuskelzellen in vitro
(2014-06-26)Toxoplasma gondii is one of the most common intracellular protozoan parasites worldwide and an important human pathogen. Its life cycle includes three stages: sporozoites, tachyzoites and bradyzoites. While sporozoites are ... -
Impact of plant species, N fertilization and ecosystem engineers on the structure and function of soil microbial communities
(2014-02-26)Soil microbial communities are directly and indirectly influenced by a complex system of cross-interactions between different biotic and abiotic factors influencing each other, such as plant species and their respective ...