Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Stülke, Jörg Prof. Dr."
Now showing items 1-20 of 38
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A novel rRNA quality control function for Npl3 in Saccharomyces cerevisiae
(2024-03-25)In all domains of life, ribosomes are essential complexes that are the sole source for protein synthesis. Ribosome biosynthesis, the most energy-consuming process in a cell, has to be tightly regulated. Misregulation ... -
Structure-based Search for novel c-di-AMP Synthase Inhibiting Fragments
(2023-03-24)One of the major threats for the global health system is the increasing number of antibiotic resistant bacterial strains. The misuse of antibiotics during the Covid pandemic aggravates these problems. Therefore, the ... -
Functions of the Cold Shock Proteins in Bacillus Subtilis
(2021-07-09)RNA binding proteins are fundamental to the proper functioning of all cells. They are structural components in larger complexes such as ribosomes or regulate cellular processes that involve RNA such as transcription, ... -
Impact of rainforest conversion: How prokaryotic communities respond to anthropogenic land use changes
(2020-12-03)In this thesis, the impact of rainforest conversion to the managed land use systems jungle rubber, rubber plantation and oil palm plantation on structure and function of soil microbial communities was investigated. The ... -
Assessment of antibiotic resistance in soil and its link to different land use types and intensities
(2020-07-15)Nowadays, bacterial infections pose a serious risk for human health again, due to multi-resistant pathogens insensitive to antibiotic treatment. Some of the antibiotic resistance genes (ARGs) carried by these pathogens ... -
Bacillus subtilis biofilm formation under extreme terrestrial and simulated extraterrestrial conditions
(2020-05-25)Since the Apollo 16 mission in 1972, Bacillus subtilis served as bacterial model organism in space. Due to the ability to form highly resistant endospores and complex biofilms, it was used to investigate the effects of ... -
Insights into the regulation of RNA helicases by protein cofactors
(2019-02-12)RNA helicases comprise a large family of ubiquitously expressed enzymes that remodel RNA structures and RNA-protein complexes in an NTP-dependent manner. These proteins are essential regulators of every RNA-related process, ... -
Funktionale Analyse des CC-Typ Glutaredoxin ROXY19 in Arabidopsis thaliana
(2019-02-05)Glutaredoxins are small widespread enzymes that are characterized by the so-called thioredoxin fold. They have an active center which can be reduced by glutathione. The glutaredoxins are divided into three classes according ... -
Cyclic monophosphate cyclase in Firmicutes: from basic to practical approach
(2019-01-30)Cyclic di-adenosine monophosphate (c-di-AMP) is a second messenger involved in diverse metabolic processes such as cell wall homeostasis, biofilm formation, antibiotic and heat resistance, among others. In Lactococcus ... -
Impact of Toxoplasma gondii on STAT1 activity and epigenetic regulation during IFN-γ signaling of its host cell
(2018-08-21)Toxoplasma gondii is an obligate intracellular parasite which infects up to 30% of humans world-wide. To control T. gondii, the host mounts a strong IFN-γ-driven immune response via the signal transducer and activator of ... -
Characterization of proteins of the Asp23 protein family in Bacillus subtilis
(2017-02-07)The acetyl-CoA carboxylase (ACCase) catalyzes the production of malonyl-CoA, the precursor in fatty acid biosynthesis. In almost all organisms, this is a fundamental process since fatty acids are the main components of ... -
The development of an integrated database of the model organism Bacillus subtilis
(2016-01-25)In the era of “Omics” approaches, the available data is exponentially increasing and new methods must be invented to handle this data. For this purpose, databases store, maintain and provide the data, and algorithms ... -
Novel virulence determinants in Mycoplasma pneumoniae: Contribution of transport systems and H2S production to viability and hemolysis
(2015-06-02)The human pathogen Mycoplasma pneumoniae is a remarkable minimal organism which primarily colonizes the human lung tissue. To reach distant infection sites, it probably also enters the blood stream. The Mycoplasma genome ... -
Functional Characterisation of Ribosome Biogenesis Cofactors in Saccharomyces cerevisiae
(2015-02-11)The biogenesis of eukaryotic ribosomes is a highly complex and dynamic process, which requires a multitude of cofactors. In Saccharomyces cerevisiae, approximately 200 proteins have been identified to function in this ... -
A method for the genetically encoded incorporation of FRET pairs into proteins
(2014-09-03)Proteins are composed of 20 canonical amino acids whose unique arrangements predefine a protein’s structure and function. Importantly, most proteins are not static conformations but rather very dynamic entities that undergo ... -
Zelltyp-spezifische Interaktionen von Toxoplasma gondii und murinen Skelettmuskelzellen in vitro
(2014-06-26)Toxoplasma gondii is one of the most common intracellular protozoan parasites worldwide and an important human pathogen. Its life cycle includes three stages: sporozoites, tachyzoites and bradyzoites. While sporozoites are ... -
Identifizierung und Charakterisierung der Dihydroorotat Dehydrogenase als Zielstruktur von 1-Hydroxyquinolonen in Toxoplasma gondii
(2014-01-06)1-Hydroxyquinolones were recently described as effective inhibitors of Toxoplasma gondii replication. These compounds (e.g. HDQ and compound B) were previously shown to inhibit the alternative NADH dehydrogenase (NADH2-I) ... -
Monitoring von Membranen und membrangebundenen Dehydrogenasen in Essigsäurebakterien
(2013-11-20)The occurrence of intracytoplasmic membranes (ICM) in Gluconobacter oxydans was first described by Claus et al. in 1975. The presence of the ICM was observed during the early stationary growth phase. It was proposed, that ... -
Untersuchung zur kohlenstoffabhängigen Wasserstoffperoxidproduktion und Virulenz in Mycoplasma pneumoniae und Mycoplasma genitalium
(2013-05-15)The human pathogens M. genitalium and M. pneumoniae use hydrogen peroxide as an important virulence factor. It could be shown that the glycerol-3-phosphate dehydrogenase (GlpD) is the key enzyme for the production of this ... -
Regulation der Aktivität und Lokalisation von Antiterminatorproteinen der BglG-Familie
(2012-11-12)The regulation of gene expression is essential for all bacteria and allows adapting to changing life conditions. Different transcription and translation factors have an important impact on gene regulation. The antermination ...