Blättern Fakultät für Chemie (inkl. GAUSS) nach "Diederichsen, Ulf Prof. Dr." Betreuer
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Synthesis of Modified and Labelled Lipids for Analysis of Enzyme Mechanisms and Membrane Interactions
(2017-11-21)Communication is key. The development of language represents a milestone in human evolution history. Long before verbal communication evolved, other, more essential forms of information transfer have arisen. The necessity ... -
Synthesis of Modified Biomolecules to Investigate Neuronal Processes
(2021-04-30)Action potentials are an essential process for signal transmission in excitable cells. At chemical synapses, the action potential triggers the release of neurotransmitters from synaptic vesicles to transmit the signal to ... -
Synthesis of new, rigid and conformation stabilizing spin labels for analysis of the orientation of transmembrane domains
(2021-11-15)Lipid-peptide interactions are involved in many essential processes of living organisms, such as cell fusion or transport processes and are therefore, in the center of research interest. One efficient technique to analyze ... -
Synthesis of Orotidine-5'-monophosphate modifications for the study of the catalytic activity of the enzyme Orotidine-5'-monophosphate decarboxylase
(2022-01-27)In this thesis, the synthesis of OMPD substrate analogs was investigated to further elucidate the mechanism of the OMPD. As inhibiting molecules, 6-thioamido UMP, OMP methyl ester, reduced OMP, and nonpolar substituted ... -
Synthesis of rare nucleobases and artificial nucleotides for investigation of catalytic enzyme activity
(2019-10-25)Enzymes are involved in replication, transcription and translation of DNA, as well as the synthesis of nucleobases. The roles and mechanisms for many of these enzymes stay broadly unknown until today. The herein presented ... -
Synthesis of Rigid Spin Labels for the Investigation of Transmembrane Peptides by EPR Spectroscopy
(2018-04-27)Transmembrane model peptides enable the investigation of complex protein-lipid interactions since the specific structure of proteins is influenced by the lipid environment. Herein, the synthesis of nitroxide spin labels ... -
Synthesis of β-Peptides for the Organization as Helix Bundles in Lipid Membranes
(2021-12-03)In this work, syntheses and analyses of transmembrane β-peptides were performed. On the one hand, a novel β-peptidic molecular ruler was designed which enables the measurement of near-membrane ion concentrations. On the ... -
Synthesis, characterisation and sensor-functionalisation of transmembrane β-peptides
(2019-07-31)Membrane proteins represent an important class of proteins as they are encoded in up to 30 % of the open reading frame. More than 50 % of currently available drugs target membrane proteins, emphasising the importance of ...