Browsing Fakultät für Physik (inkl. GAUSS) by Referee "Salditt, Tim Prof. Dr."
Now showing items 1-20 of 65
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STED microscopy with two-photon photoactivation in the visible range & Application of generative adversarial networks for image reconstruction in STED microscopy
(2023-01-31)The resolution limit of classical optical far-field microscopes was broken with the invention of super-resolution microscopy. Today, a variety of these techniques achieving different degrees of resolution exist. Image formation ... -
A matter of brightness: table-top X-ray generation inside waveguides and X-ray holography with single free-electron laser pulses
(2022-03-22)X-ray microscopy delivers insights into the structure of optically opaque bulk specimens with high spatial resolution. The source brightness poses a limit on the achievable resolution, however. While table-top X-ray sources ... -
Studying the Dynamics and Inhibition of Vimentin Assembly by Small-Angle X-ray Scattering
(2022-03-01)In this work, various methods are employed to investigate different aspects of the vimentin intermediate filament assembly process. Small-angle X-ray scattering provides insights on the occurring lateral assembly on the ... -
Low-dose, high-throughput scanning small-angle X-ray scattering of adherent mouse embryonic fibroblasts
(2022-02-24)Biological cells are highly variable: differences in e. g. gene expression emerge even among monoclonal cells in the same culture dish. The characterization of a highly variable statistical population calls for high-throughput ... -
Vesicle Adhesion, Fusion, and Neurotransmitter Uptake Studied by Small-Angle X-ray Scattering
(2022-02-15)Synaptic neurotransmission is a highly complex and crucial process in the communication between neuronal cells, and is thus directly related to the complex functions of the neural system, including information processing ... -
Localizing and tracking of single molecules with a MINFLUX-microscope for various applications
(2022-01-25)Recently MINFLUX microscopy was first published, a technique that localizes single fluorescent molecules by probing with a structured illumination excitation beam featuring a central intensity minimum. Single nanometer ... -
Quantum Sensing with NV Centers in Diamond
(2019-10-22)This thesis is concerned with studies involving quantum sensing based on Nitrogen-Vacancy (NV) center in diamond. Essentially, it attempts to address two important problems. First, enhancing the sensitivity of a single ... -
isoSTED microscopy for live cell imaging
(2019-05-08)Far-field fluorescence microscopy is a versatile tool for the non-invasive investigation of intracellular structures and thus for live cell imaging. This is a major advantage over other microscopy methods such as electron ... -
Characterization and Control of Wave Propagation in the Heart
(2019-04-12)The heart is an excitable medium which supports the propagation of waves of electrical excitation. While these excitation waves enable the normal functioning of the heart, they also allow for self-sustained arrhythmic ... -
Statistical analysis methods for time varying nanoscale imaging problems
(2019-03-28)Microscopy is a valuable imaging method in life sciences. It was thought for a long time that its resolution was fundamentally limited by diffraction, described by Abbe's resolution limit. But this limit only takes into ... -
Modeling electrodynamics in the vicinity of metal nanostructures
(2019-03-08)In this work, we show how a profound theoretical understanding of a seemingly exotic phenomenon, namely the influence of metal structures on fluorescence lifetimes, has lead to the development of a microscopy technique ... -
Hochauflösende Bildgebung und NEXAFS-Spektroskopie mit weicher Röntgenstrahlung aus laserinduzierten Plasmen
(2019-01-24)Soft x-ray microscopy and absorption spectroscopy are extremely useful tools for high-resolution imaging and chemical analysis of samples in various scientific fields. However, due to the required high photon flux of ... -
Multiscale X-Ray Analysis of Biological Cells and Tissues by Scanning Diffraction and Coherent Imaging
(2018-12-13)The past 70 years of muscle research have profoundly shaped our current understanding of the structure and function of muscle. X-ray diffraction became a key method in its structural analysis and yielded valuable insights ... -
Coordinate-targeted optical nanoscopy: molecular photobleaching and imaging of heterostructured nanowires
(2018-11-22)Super-resolution far-field fluorescence microscopy (optical nanoscopy) is a mature set of methods which enable visualization of the nanometer-scale distribution of objects such as organic molecules, photoswitchable proteins, ... -
Next-Generation Ultrafast Transmission Electron Microscopy – Development and Applications
(2018-08-22)The present cumulative thesis covers the development and applications of a novel type of ultrafast transmission electron microscope (UTEM) employing high-coherence electron pulses from a nanoscale photocathode. Specifically, ... -
3d virtual histology of neuronal tissue by propagation-based x-ray phase-contrast tomography
(2018-07-05)Deciphering the three-dimensional (3d) cytoarchitecture of neuronal tissue is an important step towards understanding the connection between tissue function and structure and determining relevant changes in neurodegenerative ... -
Time-resolved X-ray phase-contrast tomography
(2018-06-27)X-ray tomography allows to obtain the three-dimensional (3d) structure of weakly interacting objects, such as tissue samples in biomedical imaging or nanoscale structures in materials science, with high spatial resolution. ... -
Intelligent-Illumination STED
(2018-04-10)Recently established fluorescence superresolution microscopy techniques, such as stimulated emission depletion (STED), are capable of imaging fixed and living cells at the nanometer scale. In STED, ON- and OFF-switching ... -
X-Ray Near-Field Holography: Beyond Idealized Assumptions of the Probe
(2017-11-08)All images are flawed, no matter how good your lenses, mirrors etc. are. Especially in the hard X-ray regime it is challenging to manufacture high quality optics due to the weak interaction of multi-keV photons with matter. ... -
Nanoscale Waveguiding Studied by Lensless Coherent Diffractive Imaging using EUV High-Harmonic Generation Source
(2017-07-24)The challenge of nanometric imaging drives intense efforts in applied sciences and fundamental research. Following the physical law of diffraction, the utilization of extreme ultraviolet (EUV) or X-ray radiation for imaging ...