Blättern Naturwissenschaften, Mathematik und Informatik nach Betreuer & Gutachter "Ackermann, Lutz Prof. Dr."
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Electrochemical C–H Activation by Ruthenium and Palladium Catalysis
(2024-04-19)The emergence of direct functionalizations of C−H bonds offers efficient alternatives to traditional cross-coupling reactions, thereby saving time and costs. However, oxidative C−H activation often depends on stoichiometric ... -
Sustainable Ruthenium- and Rhodium-Catalyzed C−H Activations with Photochemistry and Electrochemistry
(2024-03-18)Cross-coupling chemistry stands out as a fundamental tool in synthetic organic chemistry for forging C‒C and C‒Het bonds. However, the necessity for substrate prefunctionalization imposes significant sustainability challenges ... -
Chemically- and photo-convertible dyes for fluorescence detection of biomolecules
(2024-01-24)Further progress in fluorescence microscopy and nanoscopy depends, among other factors, on the ease of detection, analysis, and selective imaging of bioconjugates prepared from fluorescent dyes with reactive groups and ... -
Diversity-Oriented Assembly of C-Glycosides via Late-Stage C−H Glycosylation
(2023-08-29)C-glycosides are widely distributed structural motifs found in natural products and commercially available drug molecules. Due to the stability of glycosidic C-C bonds against chemical and enzymatic hydrolysis, only ... -
Sustainable Methods in C–H Functionalizations
(2023-05-30)Cross-coupling chemistry has matured in an attractive tool in synthetic organic chemistry to realized efficient formation of C‒C and C‒Het bonds. However, these transformations are also associated with certain drawbacks, ... -
Mikroskopische Reaktivität Metallorganischer Spezies
(2023-03-15)In oder to better understand cross-coupling reactions, the oxidative addition between organo halides and organometallates based on iron, cobalt and copper was investigated by using ion-molecule reactions in the gas phase. ... -
Electrochemical Benzylic C−H Fluorination and 4d-Metallaelectro-Catalyzed C−H and C−C Functionalizations
(2023-03-15)Direct functionalizations of C−H and C−C bonds have emerged as time-saving and cost-effective alternatives to established cross-coupling reactions. However, oxidative coupling variants require stoichiometric amounts of ... -
Transition Metal- and Electro-Catalyzed C-H and B-H Activation for the Efficient Synthesis of Carborane Derivatives
(2023-01-12)The emergence and rapid development of transition metal-and electro-catalyzed C-H activation has proven to be a powerful tool in the assembly of complex molecular structures. in addition, the selective synthesis of carborane ... -
C–H Activation via Iridium and Rhodium Electrocatalysis and Undirected Electrochemical Fluorination
(2022-06-24)In past decades, transition metal-catalyzed C–H activation has emerged as an increasingly viable toolbox for the step- and atom economic formation of C–C and C–Het bonds. However, oxidative C–H transformations heavily rely ... -
Towards a total synthesis of bazzanin K
(2022-05-31)Bazzanin K is a natural product from the group of macrocyclic bis-bibenzyls which was isolated from the liverwort bazzania trilobata. This work is dedicated towards the development of a synthetic strategy with bazzanin K ... -
Application of Asymmetric Gold-Catalyzed Hydroarylation in the Enantioselective Synthesis of Helicenes
(2022-04-07)A novel family of electron deficient, α-cationic ligands was synthesized, combining a chiral TADDOL-backbone with an electron withdrawing 1,2,3-triazolium moiety. Coordination to Au(I) gave the respective catalysts. Both ... -
Late-Stage Peptide Functionalization by Transition Metal-free and Palladium-Catalyzed C–H Arylations
(2022-03-31)The focus of this thesis was set on the late-stage modification of peptides through transition metal-free and palladium-catalyzed C–H arylations. At first, the scope of the transition metal-free C2-arylation of the ... -
Synthesis of Orotidine-5'-monophosphate modifications for the study of the catalytic activity of the enzyme Orotidine-5'-monophosphate decarboxylase
(2022-01-27)In this thesis, the synthesis of OMPD substrate analogs was investigated to further elucidate the mechanism of the OMPD. As inhibiting molecules, 6-thioamido UMP, OMP methyl ester, reduced OMP, and nonpolar substituted ... -
Electrochemical C-H Activations with 3d and 4d Transition Metal Catalysts
(2021-12-20)The oxidative metal-catalyzed C–H activation of inert bonds is a powerful tool for the functionalization of complex molecules. This platform allowed the broadening of the organic chemists’ toolbox and improved the ... -
Earth-Abundant Transition Metal-Catalyzed Electro-Reductive Cross-Electrophile Coupling Reactions and C–H Activation by Cobaltaelectro-Catalysis
(2021-12-13)Within the last decades, immense progresses have been made with transition metal-catalyzed cross-electrophile reactions and C–H activation reactions. The merger of electrocatalysis with such powerful methods have further ... -
Chelation-Assisted C–H Activation by Ruthenium and Osmium Catalysts and Recyclable Hybrid Catalysts
(2021-10-25)Since hydrocarbons are omnipresent structural units in organic compounds, the utilization of C–H bonds of hydrocarbons has great potential. Thereby, organic chemists have had utmost interests in the transformation of ... -
Selective C-H Activation: Ruthenaelectro-Catalysis and Carborane Cage Activation
(2021-10-05)Synthetic organic chemistry mainly focuses on the cleavage and formation of bonds in a practical and selective fashion, where the formation of carbon-carbon (C-C) and C-Heteroatom (C Het) bonds constitutes one of the most ... -
Merging Electrosynthesis with 3d Transition Metal-Catalyzed C–H Transformations
(2021-07-12)In recent years, oxidative C–H transformations have emerged as increasingly powerful tools in molecular syntheses. However, despite great progress towards more atom and step economic synthetic methods, oxidative couplings ... -
Resource-Economical C–H Activation for Late-Stage Functionalization
(2021-07-07)Organic synthesis has traditionally relied on step-, time- and resource-intensive strategies, namely the functional group interconversion and, more recently, on cross-coupling reactions. These approaches have enabled the ... -
Resource-Economical Synthesis by Selective Metal-Catalyzed C–H Activations
(2021-04-30)The advent of new synthetic strategies has enriched the synthetic organic chemistry to access molecules with tremendous complexity. In this context, transition metal-catalyzed C−H activation has emerged as a powerful tool ...