Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Habeck, Michael Dr."
Now showing items 1-6 of 6
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Computational methods for random tomography with applications to cryo-EM data
(2022-08-01)Over the last decade, Cryo Electron Microscopy (cryo-EM) has emerged as a powerful and reliable technique to determine the three-dimensional (3D) structure of large macro-molecular assemblies at near atomic resolution. ... -
Improving electron microscopic hardware to push the resolution limits in single particle cryo-EM
(2022-07-19)Electron cryomicroscopy (cryo-EM) is a powerful tool in structural biology for determining 3D structures of macromolecular complexes. In the previous decade, many technological advancements have been introduced to improve ... -
Towards validation and map quality assessment in electron cryo-microscopy
(2020-09-10)Structural biology is the study of the assembly of proteins and protein complexes. These proteins and protein complexes are small units in the cell of a living being. In order to sustain life they take care of biochemical ... -
Probabilistic models for protein conformational changes
(2020-06-09)Proteins are macromolecules that perform multiple functions. They are not rigid molecules, but instead proteins can change their conformation to perform critical tasks driven by binding small ligands, by assembling into ... -
Multiscale Change-point Segmentation: Beyond Step Functions
(2017-03-08)Many multiscale segmentation methods have been proven to work successfully for detecting multiple change-points, mainly because they provide faithful statistical statements, while at the same time allowing for efficient ... -
A Bayesian approach to initial model inference in cryo-electron microscopy
(2016-03-18)Single-particle cryo-electron microscopy (cryo-EM) is widely used to study the structure of macromolecular assemblies. Tens of thousands of noisy two-dimensional images of the macromolecular assembly viewed from different ...