Einfluss von Mifamurtid auf die Makrophagen-induzierte Tumorinvasion von Brustkrebszellen
The influence of Mifamurtid on the macrophage-induced tumorinvasion of breastcancer
von Jonas Jautz
Datum der mündl. Prüfung:2019-07-31
Erschienen:2019-07-31
Betreuer:Prof. Dr. Tobias Pukrop
Gutachter:Prof. Dr. Tobias Pukrop
Gutachter:Prof. Dr. Holger Reichardt
Dateien
Name:Dr.-Arbeit Stand 2019_online_endfassung.pdf
Size:2.41Mb
Format:PDF
Zusammenfassung
Englisch
Worldwide, breast cancer is the most-common invasive cancer in women. Despite of advancing treatment options, women still die due to dissemination and metastasis formation. It is known that tumor-associated macrophages (TAMs) promote tumor invasion and metastasis of breast cancer cells. In this dissertation the effect of Mifamurtid, a potent immunomodulator approved for the treatment of progressive osteosarcoma, on the macrophage-induced tumor invasion was analyzed. The results showed that Mifamurtid causes a significant reduction in macrophage-induces tumor invasion. However, a direct effect on tumor invasion was detected and it was shown that different breast cancer cell lines express the potential receptors for Mifarmutid in a varying degree. Therefore, it needs to be further elucidated, whether the here shown effect is due to an activation of the macrophages or result from a direct effect on the tumor cells.
Keywords: macrophage-induced tumor invasion