| dc.contributor.advisor | Meyer, Thomas Prof. Dr. | |
| dc.contributor.author | Vonhören, Lara Marie | |
| dc.date.accessioned | 2020-05-29T11:52:02Z | |
| dc.date.available | 2020-06-23T22:50:03Z | |
| dc.date.issued | 2020-05-29 | |
| dc.identifier.uri | http://hdl.handle.net/21.11130/00-1735-0000-0005-13BA-4 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-7980 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-7980 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Assoziation psychometrisch erfasster depressiver Symptomatik mit dem Expressionsgrad von NF-kB bei inflammatorischen Erkrankungen des Gastrointestinaltraktes | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Association of psychometrically recorded depressive symptoms with the expression level of NF-kB in inflammatory diseases of the gastrointestinal tract | de |
| dc.contributor.referee | Meyer, Thomas Prof. Dr. | |
| dc.date.examination | 2020-06-16 | |
| dc.description.abstracteng | The transcription factor NF-kB (nuclear factor-kappa B) plays an important role in the
regulation of the immune responses, cell proliferation and apoptosis. The present clinical trial tested the hypothesis that there is a positive correlation between NF-kB expression in inflammatory gastrointestinal tissue and psychometrically assessed, self-rated depression. A total of 52 patients were included in this prospective monocenter, observational study in whom biopsies were taken in a gastroscopic (n = 32) or colonoscopic examination (n = 20). In histological sections of the specimens, immunohistochemical stainings were performed to evaluate the level of NF-kB, MPO (myeloperoxidase) and iNOS (inducible nitric oxide synthase) expression. Prior to the endoscopic procedure, self-rated anxiety and depression were assessed using the German version of the Hospital Anxiety and Depression Scale (HADS) and individual quality of life was rated using the SF-36 questionnaire. The results showed that in total 40% (21/52) of the study cohort displayed positive HADS depression scores above the clinically relevant cut-off of ≥8. There was a positive and significant association between HADS depression and the expression level of NF-kB in samples from the upper gastrointestinal tract. Statistically significant relationships between the degree of NF-kB
immunoreactivity and the anxiety score or quality of life were not found. However, there was a significant correlation between NF-kB and iNOS expression levels. In summary, the study demonstrated a significant correlation between NF-kB expression in inflammatory gastrointestinal tissue and depression. Evidence of a similar association with comorbid anxiety was not found. Further investigations are needed to confirm these relationships and to identify the involved pathophysiological mechanisms. | de |
| dc.contributor.coReferee | Schwörer, Harald Prof. Dr. | |
| dc.subject.eng | NF-kB | de |
| dc.subject.eng | HADS-D | de |
| dc.subject.eng | SF-36 | de |
| dc.subject.eng | inflammatory gastro-intestinal tissue | de |
| dc.subject.eng | depression | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-13BA-4-1 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | GOK-MEDIZIN | de |
| dc.description.embargoed | 2020-06-23 | |
| dc.identifier.ppn | 169907156X | |