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Resource-Economical Synthesis by Selective Metal-Catalyzed C–H Activations

dc.contributor.advisorAckermann, Lutz Prof. Dr.
dc.contributor.authorDhawa, Uttam
dc.publisherNiedersächsische Staats- und Universitätsbibliothek Göttingende
dc.titleResource-Economical Synthesis by Selective Metal-Catalyzed C–H Activationsde
dc.contributor.refereeAckermann, Lutz Prof. Dr.
dc.description.abstractengThe advent of new synthetic strategies has enriched the synthetic organic chemistry to access molecules with tremendous complexity. In this context, transition metal-catalyzed C−H activation has emerged as a powerful tool for highly step- and atom- economical synthesis that avoids laborious prefunctionalizations of starting materials. First part of the thesis was focused on removable directing group assisted challenging C–F/C–H functionalization using versatile manganese(I) and ruthenium(II) catalysis manifold. As with fluorinated scaffolds, chiral molecules represent a class of highly desirable building blocks. Thus, the next part of the thesis focused on the development of sustainable enantioselective transformations using cost-effective transition metals. Similarly, metallaelectrocatalysis provides excellent resource economy for sustainable organic synthesis. A major portion of the thesis was focused on addressing improved sustainability and resource-economy for the activation of inert C–H bonds. The prime focus of the thesis was the development of cost-effective and environmentally-benign metal-catalyzed selective C−H activation reactions with olefins and alkynes with a major emphasis on the identification of resource-economical conditions. In addition, a considerable focus has been placed on the mechanistic understandings of these C−H
dc.contributor.coRefereeAlcarazo, Manuel Prof. Dr.
dc.contributor.thirdRefereeTietze, Lutz Prof. Dr. Dr.
dc.contributor.thirdRefereeMata, Ricardo Prof. Dr.
dc.contributor.thirdRefereeJohn, Michael Dr.
dc.contributor.thirdRefereeJanßen-Müller, Daniel Dr.
dc.subject.engChiral Acidde
dc.subject.engC–H Activationde
dc.subject.engAsymmetric Catalysisde
dc.subject.engHomogenous Catalysisde
dc.subject.engTransition Metal Catalysisde
dc.subject.engC–F Activationde
dc.affiliation.instituteFakultät für Chemiede
dc.subject.gokfullChemie  (PPN62138352X)de

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