Self-organization of microtubules for biomimetic structures
von Smrithika Subramani
Datum der mündl. Prüfung:2019-10-14
Erschienen:2021-07-05
Betreuer:Dr. Isabella. Guido
Gutachter:Prof. Dr. Jörg Enderlein
Gutachter:Prof. Dr. Stefan Klumpp
Dateien
Name:thesis_final_version_SS.pdf
Size:18.8Mb
Format:PDF
Description:Smrithika Subramani thesis
Zusammenfassung
Englisch
Biological polymers that build up the eukaryotic cytoskeleton exhibit a rich dynamical behaviour that aid a multitude of cellular processes. Microtubules, together with their associated motor proteins in the cell are involved in cell motility, mitosis, intracellular transport and maintaining cellular rigidity. In the recent past, synthetic microtubule-motor protein systems have been extensively studied owing to their collective display of higher-level self-organization through spontaneous beating, dynamic pattern formation in dense suspensions and enhanced transport through cytoplasmic streaming. In this work, we focus on understanding microtubule-motor protein interactions through an in vitro bottom-up approach.We gain information on the motor protein induced dynamics on pairs or bundles of sliding microtubule bundles as well as crosslinked microtubule networks. As a result, we move a step closer towards gaining a better understanding of biological phenomena such as ciliary beating and cytoplasmic streaming.
Keywords: Microtubules; Motor proteins; Self-organization