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Direct, indirect and longitudinal immunological effects of anti-CD20 mediated B cell depletion in Multiple Sclerosis

dc.contributor.advisorWeber, Martin Prof. Dr.
dc.contributor.authorNissimov, Nitzan
dc.titleDirect, indirect and longitudinal immunological effects of anti-CD20 mediated B cell depletion in Multiple Sclerosisde
dc.contributor.refereeLühder, Fred PD Dr.
dc.description.abstractengB cell depletion via anti-CD20 antibodies is a highly effective treatment for multiple sclerosis (MS). However, little is known about the maturation/activation stage of the returning B cell population after treatment cessation and the wider effects on other immune cells. In the present study, 15 relapsing-remitting MS patients receiving 1,000 mg of rituximab were included. B, T, and myeloid cells were analyzed before anti-CD20 administration and in different time intervals thereafter over a period of 24 mo. In comparison to the phenotype before anti-CD20 treatment, the reappearing B cell pool revealed a less mature and more activated phenotype: 1) reappearing B cells were significantly enriched in transitional and mature naive phenotypes; 2) the frequency of memory B cells was reduced; and 3) reappearing B cells showed an enhanced expression of activation markers CD25 and CD69, and expressed significantly higher levels of costimulatory CD40 and CD86. T cells showed 1) a persistent increase in naive and 2) a decrease in terminally differentiated
dc.contributor.coRefereeWienands, Jürgen Prof. Dr.
dc.subject.engmultiple sclerosisde
dc.subject.enganti-CD20 therapyde
dc.subject.engB cellsde
dc.subject.engT cellsde
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.subject.gokfullNeurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)de
dc.subject.gokfullNeuroanatomie, Neurophysiologie, Neuropathologie (PPN619876255)de

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