The effect of glatiramer acetate on functional properties of B lymphocytes in patients with MS
von Zivar Hajiyeva
Datum der mündl. Prüfung:2021-12-08
Erschienen:2021-11-29
Betreuer:Prof. Dr. Martin Weber
Gutachter:Prof. Dr. Peter Huppke
Gutachter:Prof. Dr. Alexander Flügel
Dateien
Name:Doktorarbeit 19.11.2021.pdf
Size:2.78Mb
Format:PDF
Zusammenfassung
Englisch
Objective: We examined the effect of glatiramer acetate (GA) on B-cell maturation, differentiation, and antigen presentation in MS patients. Methods: A cross-sectional study of blood samples from 20 GA-treated and 18 untreated patients with MS was performed by flow cytometry; 6 GA-treated patients with MS were analyzed longitudinally. Results: In MS, GA diminished transitional B-cell and plasmablast frequency, downregulated CD69, CD25, and CD95 expression, and decreased TNF-α production, whereas IL-10 secretion and MHC Class II expression were increased. Conclusions: GA immune modulates B-cell function in MS.
Keywords: B cells; Multiple sclerosis; glatiramer acetate