Synthesis of β-Peptides for the Organization as Helix Bundles in Lipid Membranes
von Martin Kloos
Datum der mündl. Prüfung:2021-11-12
Erschienen:2021-12-03
Betreuer:Prof. Dr. Ulf Diederichsen
Gutachter:Prof. Dr. Claudia Steinem
Gutachter:Prof. Dr. Kai Tittmann
Dateien
Name:SUB Dissertation Martin Kloos.pdf
Size:3.81Mb
Format:PDF
Zusammenfassung
Englisch
In this work, syntheses and analyses of transmembrane β-peptides were performed. On the one hand, a novel β-peptidic molecular ruler was designed which enables the measurement of near-membrane ion concentrations. On the other hand, transmembrane β-peptides were investigated in terms of self-aggregation in lipid membranes. The use of the recognition units cyanuric acid (CA) and melamine (M) as well as the pure transmembrane domain were found to assemble in the lipid environment leading to new applications in the field on transmembrane β-peptides.
Keywords: β-peptides; grapheneMIET; Molecular Ruler; Peptide Aggregation