Dokumente Molekulare Medizin nach Gutachter "Dobbelstein, Matthias Prof. Dr."
Anzeige 21-29 von 29
-
Targeting MDM2, the antagonist of the tumor suppressor p53
(2018-09-19)p53 is one of the most extensively studied tumor suppressor proteins, and its gene is mutated in 50% of human cancers. Stress signals activate p53 and its transcriptional machinery which lead to cell-cycle arrest, apoptosis ... -
Targeting the Hedgehog and PI3K/AKT/mTOR signaling pathways in rhabdomyosarcoma
(2018-12-18)Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS, and especially the embryonal subtype (ERMS), show activation of Hedgehog (HH) signaling. In patients with Gorlin syndrome, ... -
The influence of valproic acid and the role of cyclin D2 in prostate cancer
(2016-10-11)Prostate cancer (PCa) is the most frequently new diagnosed cancer and the third leading cause of cancer-related deaths in men in Germany. Studies on possible agents for PCa therapy are indispensable since treatment options ... -
The Kv10.1 voltage gated potassium ion channel modulates the cell adhesion and cell migration hallmarks of cancer
(2015-06-23)A characteristic of the Kv10.1 voltage-gated potassium ion channel is its overexpression in a number of cancerous tissues and cancer cell lines, even though it should normally be restricted to the adult brain and myoblasts. ... -
The MDM2 oncoprotein antagonizes Poly(ADP-ribosyl)ation
(2023-02-23)MDM2 is a target gene product and a negative regulator of the tumor suppressor p53. Additionally, MDM2 interferes with the progression of DNA replication forks. Poly(ADP-Ribose) Polymerase 1 (PARP1) is the main ... -
The role of histone 2B monoubiquitination (H2Bub1) in HER2-driven mammary carcinoma
(2021-03-25)Breast cancer (BC) is the most frequent tumor entity in women worldwide with a high chance of therapeutic response in early- and non-metastatic disease stage. Despite the advent of HER2-specific targeted therapies, a ... -
The role of the Glucocorticoid Receptor in intestinal inflammation and tumorigenesis in a murine model of colitis and colitis-associated colorectal cancer
(2022-08-12)Ulcerative colitis (UC) is a life-threatening disease with constantly increasing incidence. Glucocorticoids (GCs) are one of the first choices for the treatment of this disease thanks to their anti-inflammatory action and ... -
TP53-status dependent oncogenic EZH2 Activity in Pancreatic Cancer
(2022-07-14)Pancreatic Ductal Adenocarcinoma (PDAC) remains a dismal malignancy with a 5-year sur-vival rate of less than 10%. Predominately, chemoresistance mediated by the dynamic cel-lular plasticity induced through epigenetic ... -
Unravelling epigenetic mechanisms of CAF-chemotherapy resistance in mammary carcinoma
(2020-01-29)Triple negative breast cancer (TNBC) is one of the most challenging cancers to treat as, despite the initial response to chemotherapy, relapse occurs frequently. In this project, we focused on the mechanisms that allow ...