Browsing Molekulare Medizin by Advisor "Brück, Wolfgang Prof. Dr."
Now showing items 1-8 of 8
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The role of the astrocytic and microglial aryl hydrocarbon receptor in CNS demyelination
(2020-11-26)The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor which plays a key role in the regulation of immune and inflammatory responses. AhR expression in astrocytes and microglia was shown to limit ... -
IFNβ as regulator of CD14/TLR4-mediated microglial responses to CNS infection and damage
(2017-02-15)Microglia are the innate immune cells of the central nervous system (CNS). They are capable of sensing infection and damage through various receptors and consequently trigger an appropriate immune response. This includes ... -
Constitutive heterogeneity and response diversity of microglia in pathological conditions
(2016-12-16)Microglia, resident myeloid cells of the CNS, execute an enormous variety of different functions like tissue surveillance, nursing of synapses, phagocytosis of foreign material or debris, and initiation of appropriate ... -
The role of astrocytes in murine models of toxic demyelination
(2016-08-30)In demyelinating diseases such as multiple sclerosis (MS) activated astrocytes, characterised by up-regulation of the intermediate filament glial fibrillary acidic protein (GFAP), were shown to have beneficial as well as ... -
The role of astrocytic RFX4_v3 in demyelination
(2015-05-11)RFX4_v3 is the brain-specific splice variant of the transcription factor RFX4 (Blackshear et al., 2003; Matsushita et al., 2005). It was shown to play an important role during early brain development and in the genesis of ... -
Axonal degeneration and protection during early remyelination in multiple sclerosis and an animal model
(2015-02-17)Axonal damage, often followed by axonal degeneration, is the main cause of persisting disabilities in multiple sclerosis (MS) patients and already occurs in early stages of the disease. Disease progression is in addition ... -
Analyzing the effects of laquinimod on innate and adaptive immunity in mice with experimental autoimmune encephalomyelitis
(2014-05-09)Laquinimod (LAQ), a new orally active immunomodulator, is currently under investigation for the treatment of multiple sclerosis (MS). In clinical trials LAQ considerably reduced the annualized relapse rate, disability ... -
Studying the Interactions of Cytotoxic T Cells with Neurons in vivo
(2013-12-13)The central nervous system (CNS) is considered as largely isolated from the immune system – a status referred to as “immune privilege”. But CNS-tissue is constantly surveyed by immune cells and can under certain circumstances, ...