Browsing Molekulare Medizin by Advisor "Brockmöller, Jürgen Prof. Dr."
Now showing items 1-4 of 4
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Stereoselectivity in Drug Membrane Transport by Solute Carriers (SLCs)
(2023-07-10)About 50% of all small molecule drugs are racemic mixtures of usually two stereoisomers. In the living organism, these drugs interact with a mostly chiral environment of unichiral amino acids, sugars, hormones, and other ... -
The Endogenous and Exogenous Substrate Spectrum of the Human Organic Cation Transporter OCT1 – a Comprehensive Characterization
(2021-07-23)The organic cation transporter 1 (OCT1) is most extensively expressed in the human liver. OCT1 is involved in the hepatic uptake of several drugs and endogenous compounds, which then undergo bioactivation, recycling, ... -
The role of membrane transporters in the pharmacokinetics of psychotropic drugs: in vitro studies with special focus on organic cation transporters
(2015-02-10)The treatment of common psychiatric disorders like major depression, schizophrenia and bipolar disorder is characterized by low efficacy and variability in the case of depression and bipolar disorder, and of undesirable ... -
Genetic polymorphisms in genes regulating renal ion excretion and diuretic drug effects
(2014-07-17)Regulation of human salt and fluid homeostasis is of basic biological importance. Kidney functions allow surviving under a wide variety of conditions with high or low salt diets and with high or low intake of fluids, even ...