Browsing Molekulare Medizin by Advisor "Burfeind, Peter Prof. Dr."
Now showing items 1-6 of 6
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The role of estrogen receptors in prostate cancer development and their role in new treatment opportunities
(2017-08-29)The androgen receptor (AR) signaling pathway is one of the key pathways deregulated in prostate cancer (PCa). Different attempts to inhibit AR signaling failed to be curative. Therefore, the targeting of other pathways ... -
Analysis of the function of the IGF1R during the development and therapy of colorectal cancer
(2016-12-06)The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase that is overexpressed in a variety of human malignancies, including colorectal cancer (CRC). In the present study, the role of the IGF1R during ... -
The influence of valproic acid and the role of cyclin D2 in prostate cancer
(2016-10-11)Prostate cancer (PCa) is the most frequently new diagnosed cancer and the third leading cause of cancer-related deaths in men in Germany. Studies on possible agents for PCa therapy are indispensable since treatment options ... -
Importance of CXCL12 and CXCR4 in radiotherapy of head and neck cancer, considering the association with HPV-infection
(2015-09-10)p16INK4A expression is an important, independent prognostic marker in HNSCC patients. We observed a strong correlation between tumour HPV status, particularly HPV-16, and p16INK4A expression. Accordingly, our data clearly ... -
Analyses on the mechanisms underlying the leupaxin-mediated progression of prostate cancer
(2015-08-19)The focal adhesion protein leupaxin (LPXN) is overexpressed in a subset of prostate cancers (PCa). Recently, LPXN was shown to be involved in the progression of prostate carcinomas. In the present study, the LPXN-mediated ... -
rAAV-based gene therapy for molybdenum cofactor deficiency type B
(2015-06-29)Molybdenum cofactor (MoCo) deficiency type A is thus far only one curable type of MoCo deficiency. In the present study, a mouse model for MoCo deficiency type B (Mocs2-/-) was generated, characterised and used for preclinical ...