Browsing Molekulare Medizin by Advisor "Gärtner, Jutta Prof. Dr."
Now showing items 1-4 of 4
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Effects of histone 3.3K27M-mutation on CREB binding protein (CBP/p300)- and bromodomain and extra terminal domain (BET) protein- mediated gene regulation in diffuse intrinsic pontine gliomas (DIPG)
(2023-04-25)Diffuse intrinsic pontine gliomas (DIPG) are incurable pediatric high-grade tumors. The majority of all DIPG carries a mutation in one of the histone 3 genes leading to a substitution of lysine 27 to methionine (H3 K27M) ... -
HID1 as a novel disease-causing gene in early onset neurological disorders: molecular, functional and phenotypic studies
(2022-09-07)Rare neurological diseases with genetic causes are gaining relevance for child morbidity and mortality due to improvements in health care, prevention and treatment of conventional life-limiting diseases in infants. Emerging ... -
Characterization of peroxisomes and peroxisome deficient cell lines by super-resolution microscopy and biochemical methods
(2016-11-25)Stimulated Transmission Emission Depletion (STED) microscopy was used to characterize the nanoscopic morphology of wild-type peroxisomes under normal and proliferative conditions in mammalian cells and in yeast Saccharomyces ... -
Lactate dehydrogenase is C-terminally extended by stop codon read-through which targets this isoform into the peroxisomes
(2016-08-12)In this work, the functional significance of stop codon read-through was investigated in relation to the human peroxisomes. When the ribosomes translating a messenger RNA encounter a stop codon, they usually stop the ...