Browsing Molekulare Medizin by Advisor "Kube, Dieter Prof. Dr."
Now showing items 1-6 of 6
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Characterization of the MIR23A Cluster in Diffuse Large B Cell Lymphoma
(2017-08-11)During B cell maturation within the germinal centers of lymph nodes, genetical alterations, such as chromosomal translocations and mutations are introduced into the genome in order to increase the B cell receptor (BCR) ... -
Dissecting and Modeling Oncogene Dependent Molecular Mechanisms in Lymphoma Genesis and Progression
(2013-11-18)Aggressive Non-Hodgkin lymphomas (aNHL) are a heterogeneous group of lymphomas. The constellation of oncogenic pathway activities can vary in patients with the same malignant disease. The pathological mechanisms behind the ... -
Hodgkin lymphoma secreted factors determine macrophage polarization and function
(2018-09-14)Hodgkin lymphoma (HL) is a unique entity where the fraction of malignant cells accounts for only 1 % of the tumor. The cells are embedded in a complex background of non-neoplastic immune infiltrates. Profound interactions ... -
Interplays and feedback loops of oncogenic signaling pathways in B cell non-Hodgkin lymphoma
(2019-02-28)The B cell receptor (BCR) signaling, required for the survival and maturation of B cells, is one major deregulated pathway in B cell lymphomas. Several mutations are known to enhance the tonic BCR signal in Burkitt lymphomas ... -
Synergism of IL10R and TLR9 signaling affects gene expression, proliferation and metabolism in B cells: A comparative study of STAT3/NF-kB and c-Myc mediated effects
(2016-10-11)The interplay of different signaling pathways activated by factors of the cellular environment and expression the proto-oncogene c-Myc (MYC) defines B cell fate in the germinal center (GC). Importantly, the same signaling ... -
WNT signalling affects cell migration, invasion and the lymphoma-endothelial interplay in Hodgkin Lymphoma
(2016-06-23)Classical Hodgkin Lymphoma (cHL) comprises a unique cancer where the microenvironment accounts for 99 % of the whole tumour mass. In cHL dissemination involves functionally neighbouring lymph nodes but the underlying ...