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    • Modulation of HSF1 activity by p53 and its impact in cancer therapies 

      Isermann, Tamara (2023-07-13)
      The tumor suppressor p53 (TP53) is mutated in ~70 % of colorectal cancer (CRC) cases. Of these cases, approximately 80 % undergo subsequent p53 loss-of-heterozygosity (p53LOH), losing the remaining wildtype p53 (WTp53) ...
    • HSP90-stabilized proteins as therapeutic targets in cancer 

      Klemke, Luisa (2021-06-25)
      Although cancer is among the most common causes of death worldwide, successful treatment options for most cancer entities remain elusive, raising the need for novel therapies. One attractive target of current drug candidates ...