Browsing Molekulare Medizin by Advisor "Thumm, Michael Prof. Dr."
Now showing items 1-5 of 5
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Structure and molecular function of WD-40 repeat-containing autophagy proteins Atg18, Atg21 and Hsv2
(2022-06-23)Autophagy is a highly regulated cellular degradation and recycling process conserved from yeast to higher eukaryotes. This process is constitutively active at a low level, and non-selectively degrades portions of the cytosol ... -
Identification and Characterization of autophagic and non-autophagic Interaction Partners of Atg18
(2021-06-03)The PROPPIN Atg18 belongs to the WD40 repeat containing family and folds into a typical seven-bladed beta-propeller. Conserved regions at blade 5 and 6 allow for binding to phosphatidylinositolphosphates and mediate the ... -
New Insights into Nucleophagy in S. cerevisiae
(2019-03-12)Nucleophagy is a specific type of autophagy, a process for the degradation of non-essential parts of the nucleus under starvation conditions. Nucleophagy can be subdivided into Atg39 and Atg40 dependent macronucleophagy ... -
Dissecting the molecular function of the ubiquitin-like Atg8 during autophagosome biogenesis in S. cerevisiae
(2018-03-23)Autophagy is a degradative pathway that is conserved from yeast to mammals. Marcoautophagy is characterized by the formation of a unique double-membrane layered vesicle, the so-called autophagosome. Proteins and organelles ... -
Dissecting molecular elements of mitophagy and the lysis of intravacuolar vesicles
(2015-10-26)Autophagy is an evolutionary conserved catabolic process essential for the recycling and removal of cytosolic components via the lysosome (vacuole). Macroautophagy is characterized by the formation of a double membrane-layered ...