Browsing Molekulare Medizin by Advisor "Wienands, Jürgen Prof. Dr."
Now showing items 1-7 of 7
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Alpha-Actinin-4 Supports B Cell Survival by Limiting Lateral BCR Mobility
(2023-10-17)The B cell antigen receptor (BCR) is involved in many cellular processes that define B cell fate. Once engaged by a cognate antigen, the BCR initiates a series of signaling cascades that drive B cell activation, proliferation, ... -
Targeting and Elimination of T Cell Subpopulations by Chimeric Antigen Receptor-modified T Cells
(2021-08-10)Chimeric antigen receptors (CARs) demonstrated a high potential for the elimination of tumor cells in cancer immunotherapy. The first successful application of CAR-expressing T cells aimed at the elimination of B cells in ... -
Analysis of the organization and signaling capacity of the membrane IgE during its interaction with CD19 and CD23 in B lymphocytes
(2021-07-27)The predominant allergy type I (hypersensitivity reaction type I) poses an increasing health issue in industrialized countries over the last decades. A key mediator in the pathogenesis of hypersensitivity or allergic ... -
Targeting JAK/STAT signalling for sensitization of colorectal cancer cells to chemoradiotherapy
(2021-07-08)Despite ever-evolving treatment and screening procedures, Colorectal cancer (CRC) remains a major cause of cancer-related deaths worldwide. Preoperative chemoradiotherapy (CRT), followed by standardized surgical resection ... -
Off the beaten path - An unbiased inventory of signal response elements in B cell receptor signaling
(2021-04-06)Signaling through the B cell antigen receptor (BCR) is indispensable for B lymphocyte maturation, activation and differentiation. Antigenic signal transduction thus constitutes a centerpiece of adaptive immunity and its ... -
Revisiting Erk signaling following B cell antigen receptor activation by different stimulatory agents
(2016-09-19)B cell antigen receptor (BCR) ligation leads to activation of a number of intracellular signaling events that decide the fate of the B cell and thus is a key event in humoral immunity. BCR activation is tightly controlled ... -
CIN85 in proximal and distant B cell antigen receptor signaling
(2016-03-15)B cell antigen receptor (BCR) signaling is pivotal in B cell development and initiation of humoral immune responses. In this process, numerous proteins are involved that interact with each other and build up a sophisticated ...