Browsing Molekulare Medizin by Advisor "Zimmermann, Wolfram-Hubertus Prof. Dr."
Now showing items 1-10 of 10
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Engineered skeletal muscle from human pluripotent stem cells to model muscle disease and regeneration
(2021-06-25)Skeletal muscle disease modeling offers the unique opportunity to investigate devastating muscle diseases like Duchenne Muscle Dystrophy in vitro but requires advanced three-dimensional (3D) model systems reflecting the ... -
A cell-type and compartment specific analysis of glutathione and hydrogen peroxide
(2019-07-04)Reactive oxygen species (ROS) have been recognized to play important roles as messenger molecules. They are involved in the etiology and progression of cardiovascular diseases such as myocardial infarction, cardiac hypertrophy ... -
Fibroblast-Cardiomyocyte Cross-Talk in Heart Muscle Formation and Function
(2019-02-01)Cardiac fibroblasts make up a considerable fraction of the total heart cell content. How cardiac fibroblasts signaling affects heart muscle function in normal heart development and disease remains, however, largely unresolved. ... -
Development of a Rhesus macaque engineered heart muscle model from pluripotent stem cells
(2017-06-13)Myocardial infarction is the leading cause of death globally. Remuscularization of the heart with stem cell based treatments is one potential approach to heart repair which is presently being tested. Proof-of-concept ... -
Development of a genetically encoded model for the sensing of glutathione redox potential in human embryonic stem cell-derived cardiomyocytes and fibroblasts
(2017-05-29)Redox alterations due to increased ROS production in heart cells have been implicated in several cardiovascular diseases, such as ischemia, hypertrophy, and myocardial infarction, but may also play a crucial role for the ... -
Characterization and Application of Bioengineered Heart Muscle as a New Tool to Study Human Heart Development and Disease
(2016-09-20)Proof-of-concept for the generation of a bioengineered heart muscle (BHM) directly from human pluripotent stem cells (hPSCs) as a model to simulate human heart muscle development was introduced recently by our lab. BHMs ... -
Control of cardiogenesis and homeostasis by cardiac fibroblasts
(2016-07-12)The mammalian heart is a complex multicellular organ which undergoes many critical changes during development and under pathological conditions. Cardiac fibroblasts (cFBs) represent the predominant non-myocyte population ... -
Characterization of cardiac progenitor cell activity in engineered heart muscle
(2016-06-21)The heart has been considered a post-mitotic organ incapable of regeneration upon injury. Recent findings suggest that the heart contains cardiac progenitor cells (CPCs) with the potential to give rise to cardiovascular ... -
Immunological properties of parthenogenetic stem cell derived cardiomyocytes and their application in cardiac tissue engineering
(2016-06-20)Cardiovascular diseases and their long term consequences constitute serious health and economic burdens. Although promising new therapeutic approaches to ameliorate the detrimental consequences have been introduced, there ...