Browsing Molekulare Medizin by Referee "Bohnsack, Markus Prof. Dr."
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Regulation of the MDM4 oncogene by the ribosomal protein L22 through alternative mRNA splicing
(2024-09-27)p53 is the most frequently mutated tumor suppressor in human cancer. By acting as a transcription factor for its target genes, it causes downstream effects such as cell cycle arrest or apoptosis. To avoid excessive p53 ... -
Alpha-Actinin-4 Supports B Cell Survival by Limiting Lateral BCR Mobility
(2023-10-17)The B cell antigen receptor (BCR) is involved in many cellular processes that define B cell fate. Once engaged by a cognate antigen, the BCR initiates a series of signaling cascades that drive B cell activation, proliferation, ... -
Insights into early biogenesis steps of the human small mitochondrial ribosomal subunit
(2021-06-28)The rise of high-resolution cryo-EM structures of the human mitochondrial ribosome increased the understanding of the function and assembly. As the mitochondrial ribosome differs in structure and composition compared to ... -
Lactate dehydrogenase is C-terminally extended by stop codon read-through which targets this isoform into the peroxisomes
(2016-08-12)In this work, the functional significance of stop codon read-through was investigated in relation to the human peroxisomes. When the ribosomes translating a messenger RNA encounter a stop codon, they usually stop the ...