Browsing Molekulare Medizin by Referee "Brockmöller, Jürgen Prof. Dr."
Now showing items 1-9 of 9
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Stereoselectivity in Drug Membrane Transport by Solute Carriers (SLCs)
(2023-07-10)About 50% of all small molecule drugs are racemic mixtures of usually two stereoisomers. In the living organism, these drugs interact with a mostly chiral environment of unichiral amino acids, sugars, hormones, and other ... -
The Endogenous and Exogenous Substrate Spectrum of the Human Organic Cation Transporter OCT1 – a Comprehensive Characterization
(2021-07-23)The organic cation transporter 1 (OCT1) is most extensively expressed in the human liver. OCT1 is involved in the hepatic uptake of several drugs and endogenous compounds, which then undergo bioactivation, recycling, ... -
The role of Ca2+ influx mechanisms in the regulation of human cardiac fibroblasts in 2D- and 3D- culture models
(2021-06-24)Cardiac fibrosis is a serious health problem commonly associated with cardiovascular diseases and remains an increasing health burden around the globe. The development of cardiac fibrosis involves the activation and ... -
Functional characterization of genetic polymorphisms in the organic cation transporter OCT1 with a special focus on the substrate-specific effects of the M420del polymorphism
(2016-06-06)The human organic cation transporter 1 (OCT1) is strongly expressed in the sinusoidal membrane of hepatocytes. OCT1 mediates the uptake of drugs and exogenous substances with cationic or weak basic structures into the ... -
The role of SNAP29 during epidermal differentiation
(2015-12-11)The human CEDNIK syndrome is caused by loss-of-function mutations in the SNAP29 gene, encoding a member of the SNARE family of proteins. So far, no Snap29-deficient mammalian animal models have been described for this rare ... -
Molecular determinants for the outcome in gemcitabine-treated pancreatic cancer
(2015-12-07)Pancreatic ductal adenocarcinoma (PDAC) is a mostly lethal disease which represents the fourth common cause of all deaths related to cancer. The nucleoside analogue gemcitabine constitutes a currently widely used treatment ... -
Cardiac and fibroblastic properties after HIF-1α stabilization
(2015-06-01)The cellular oxygen sensing prolyl-4-hydroxylase domain proteins (PHDs) are essential regulators of the α-subunit of hypoxia-inducible transcription factors (HIFs) which are known to induce a variety of genes affecting ... -
Interaction of hepatic uptake transporters with antineoplastic compounds and regulation of the expression of organic cation transporter 3 in renal carcinoma cells
(2015-02-06)The ability of a compound to exert its antineoplastic activity is determined by the amount of its accumulation inside the cell, a process largely dependent on the transporter proteins which are responsible for the passage ... -
Role of Secretory Processes in Cardiac Fibroblasts for Heart Failure Development and Progression
(2014-11-27)Cardiac fibroblasts play a major role in fibrogenesis associated with heart failure, since they produce ECM components and secrete important fibrosis-associated mediators, such as connective tissue growth factor (CTGF). ...