Browsing Molekulare Medizin by Referee "Burckhardt, Gerhard Prof. Dr."
Now showing items 1-3 of 3
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Expression von Aufnahme-Transportern für Zytostatika in Mamma- und Prostatakarzinom-Zellen und ihre Interaktion mit Zytostatika
(2017-06-27)The solute carrier (SLC) transporters form a large family of membrane proteins that translocate dissolved substances across cell membranes. The first part of this work investigates the interaction of 26 commonly used ... -
Functional characterization of genetic polymorphisms in the organic cation transporter OCT1 with a special focus on the substrate-specific effects of the M420del polymorphism
(2016-06-06)The human organic cation transporter 1 (OCT1) is strongly expressed in the sinusoidal membrane of hepatocytes. OCT1 mediates the uptake of drugs and exogenous substances with cationic or weak basic structures into the ... -
The role of membrane transporters in the pharmacokinetics of psychotropic drugs: in vitro studies with special focus on organic cation transporters
(2015-02-10)The treatment of common psychiatric disorders like major depression, schizophrenia and bipolar disorder is characterized by low efficacy and variability in the case of depression and bipolar disorder, and of undesirable ...