Browsing Molekulare Medizin by Referee "Burfeind, Peter Prof. Dr."
Now showing items 1-8 of 8
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TGFβ mediated chromosomal instability in human colorectal cancer cells
(2023-06-28)Chromosomal instability (CIN) is a major hallmark of human cancer and is defined as persistently high rate of the generation of chromosomal aberrations leading to genetic variability, tumour heterogeneity and tumour ... -
MCL-1, BCL-xL and Casp-3 as key regulators in thymus homeostasis and thymic epithelial tumors
(2021-12-23)As a primary lymphatic organ, the thymus is responsible for T cell development and the establishment of the adaptive immune system. The homeostasis and proper function of the thymus epithelium require the strict regulation ... -
The role of the astrocytic and microglial aryl hydrocarbon receptor in CNS demyelination
(2020-11-26)The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor which plays a key role in the regulation of immune and inflammatory responses. AhR expression in astrocytes and microglia was shown to limit ... -
The role of estrogen receptors in prostate cancer development and their role in new treatment opportunities
(2017-08-29)The androgen receptor (AR) signaling pathway is one of the key pathways deregulated in prostate cancer (PCa). Different attempts to inhibit AR signaling failed to be curative. Therefore, the targeting of other pathways ... -
Characterization of the MIR23A Cluster in Diffuse Large B Cell Lymphoma
(2017-08-11)During B cell maturation within the germinal centers of lymph nodes, genetical alterations, such as chromosomal translocations and mutations are introduced into the genome in order to increase the B cell receptor (BCR) ... -
Uncovering triggers of colonization in brain metastasis
(2017-04-26)Brain metastases (BM) are frequent in cancer patients and are associated with poor prognosis. The incidence of BM is increasing mainly due to an improved control of primary tumors and an increased median survival of the ... -
Molecular determinants for the outcome in gemcitabine-treated pancreatic cancer
(2015-12-07)Pancreatic ductal adenocarcinoma (PDAC) is a mostly lethal disease which represents the fourth common cause of all deaths related to cancer. The nucleoside analogue gemcitabine constitutes a currently widely used treatment ... -
Dissecting and Modeling Oncogene Dependent Molecular Mechanisms in Lymphoma Genesis and Progression
(2013-11-18)Aggressive Non-Hodgkin lymphomas (aNHL) are a heterogeneous group of lymphomas. The constellation of oncogenic pathway activities can vary in patients with the same malignant disease. The pathological mechanisms behind the ...