Browsing Molekulare Medizin by Referee "Dobbelstein, Matthias Prof. Dr."
Now showing items 1-20 of 30
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Regulation of the MDM4 oncogene by the ribosomal protein L22 through alternative mRNA splicing
(2024-09-27)p53 is the most frequently mutated tumor suppressor in human cancer. By acting as a transcription factor for its target genes, it causes downstream effects such as cell cycle arrest or apoptosis. To avoid excessive p53 ... -
Dynamics of the microbiome in pancreatic cancer from inception to invasion
(2023-10-23)Recently, the microbiome was associated with hallmark features of pancreatic ductal adenocarcinoma (PDAC). This dismal human disease with one of the lowest survival rates of below 10% is characterized by clinical challenges ... -
Impaired chromosome integrity caused by mutations in members of the BTRR complex
(2023-10-17)Bloom syndrome (BS) is an autosomal recessive rare disorder clinically characterized by primary microcephaly, growth deficiency, short stature, photosensitivity, immunodeficiency, and cancer predisposition. BS is caused ... -
Alpha-Actinin-4 Supports B Cell Survival by Limiting Lateral BCR Mobility
(2023-10-17)The B cell antigen receptor (BCR) is involved in many cellular processes that define B cell fate. Once engaged by a cognate antigen, the BCR initiates a series of signaling cascades that drive B cell activation, proliferation, ... -
Effects of histone 3.3K27M-mutation on CREB binding protein (CBP/p300)- and bromodomain and extra terminal domain (BET) protein- mediated gene regulation in diffuse intrinsic pontine gliomas (DIPG)
(2023-04-25)Diffuse intrinsic pontine gliomas (DIPG) are incurable pediatric high-grade tumors. The majority of all DIPG carries a mutation in one of the histone 3 genes leading to a substitution of lysine 27 to methionine (H3 K27M) ... -
The MDM2 oncoprotein antagonizes Poly(ADP-ribosyl)ation
(2023-02-23)MDM2 is a target gene product and a negative regulator of the tumor suppressor p53. Additionally, MDM2 interferes with the progression of DNA replication forks. Poly(ADP-Ribose) Polymerase 1 (PARP1) is the main ... -
Interfering with critical steps of the viral replication cycle to diminish SARS-CoV-2 propagation
(2022-10-07)The ongoing COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has so far infected more than 0.5 billion people worldwide, with at least 6.3 million deaths, and constitutes one of the largest global health ... -
The role of the Glucocorticoid Receptor in intestinal inflammation and tumorigenesis in a murine model of colitis and colitis-associated colorectal cancer
(2022-08-12)Ulcerative colitis (UC) is a life-threatening disease with constantly increasing incidence. Glucocorticoids (GCs) are one of the first choices for the treatment of this disease thanks to their anti-inflammatory action and ... -
TP53-status dependent oncogenic EZH2 Activity in Pancreatic Cancer
(2022-07-14)Pancreatic Ductal Adenocarcinoma (PDAC) remains a dismal malignancy with a 5-year sur-vival rate of less than 10%. Predominately, chemoresistance mediated by the dynamic cel-lular plasticity induced through epigenetic ... -
MCL-1, BCL-xL and Casp-3 as key regulators in thymus homeostasis and thymic epithelial tumors
(2021-12-23)As a primary lymphatic organ, the thymus is responsible for T cell development and the establishment of the adaptive immune system. The homeostasis and proper function of the thymus epithelium require the strict regulation ... -
Overcoming Cisplatin Resistance in Pancreatic Cancer
(2021-11-16)Pancreatic ductal adenocarcinoma (PDAC) is the most common species of pancreatic cancer with high lethality. Despite intensive research, no major therapy improvements have been achieved due to late-stage diagnosis and ... -
Targeting JAK/STAT signalling for sensitization of colorectal cancer cells to chemoradiotherapy
(2021-07-08)Despite ever-evolving treatment and screening procedures, Colorectal cancer (CRC) remains a major cause of cancer-related deaths worldwide. Preoperative chemoradiotherapy (CRT), followed by standardized surgical resection ... -
The role of histone 2B monoubiquitination (H2Bub1) in HER2-driven mammary carcinoma
(2021-03-25)Breast cancer (BC) is the most frequent tumor entity in women worldwide with a high chance of therapeutic response in early- and non-metastatic disease stage. Despite the advent of HER2-specific targeted therapies, a ... -
Interplay of ARID1A and EGFR signaling in controlling acinar cell reprogramming in the pancreas
(2021-03-18)Based on a high degree of cellular plasticity and triggered by external (e.g. inflammation) or internal (e.g. oncogenic pressure) signals, pancreatic acinar cells can undergo reprogramming processes resulting in acinar-to-ductal ... -
EZH2-GATA6 axis in Pancreatic ductal adenocarcinoma
(2020-09-25)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease which is significantly driven by epigenetic alterations, e.g. installed by overexpression of Enhancer of Zeste homologue 2 (EZH2). EZH2 constitutes ... -
Functional and diagnostic relevance of FGFR1-dependent signaling pathways in squamous cell lung cancer
(2020-09-22)Lung cancer continuous to be the leading cause of cancer-related death worldwide. A relatively new and effective approach of treating lung cancer is achieved through targeting specific molecular alterations in lung cancer ... -
Unravelling epigenetic mechanisms of CAF-chemotherapy resistance in mammary carcinoma
(2020-01-29)Triple negative breast cancer (TNBC) is one of the most challenging cancers to treat as, despite the initial response to chemotherapy, relapse occurs frequently. In this project, we focused on the mechanisms that allow ... -
Role of stromal SPARC in PDAC tumorigenesis and drug delivery
(2019-11-13)Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid tumors in humans. Median survival is around 12 months and is due to late diagnosis, early metastatic spread, and a high resistance towards available ... -
Role of RAS signaling in Hedgehog-associated embryonal rhabdomyosarcoma
(2019-01-17)Rhabdomyosarcoma (RMS) are the most common pediatric soft tissue sarcomas. RMS of the embryonal subtype (ERMS) are characterized by high expression of markers of an activated Hedgehog (HH) signaling cascade, i.e. they ... -
MiRNAs and tumor suppressors form a gene regulatory network to protect multiciliogenesis
(2019-01-10)Multiple motile cilia are present on specialized epithelial cells lining the airways, reproductive ducts, and brain ventricles. Cilia beating contributes to fluid movement and particle transport along the multiciliated ...