Browsing Molekulare Medizin by Referee "Dressel, Ralf Prof. Dr."
Now showing items 1-20 of 24
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Subcellular compartmentalization of signal elements and their re-distribution in resting and activated B cells
(2024-09-19)BCR activation triggers a complex network of pathways and cascades, shaping the fate of B cells. This process is influenced by co-receptors as well as co-stimulatory molecules, among others. Dysregulation in this process ... -
3D imaging of immune cell reaction in pancreatic cancer organoids: the response to a nanovaccine therapy
(2024-06-27)This PhD thesis explored the use of patient-derived organoids (PDOs) obtained from tumor tissue, to address research limitations and therapeutic challenges in pancreatic ductal adenocarcinoma (PDAC), characterized by a ... -
Evaluation of synergistic hybrid nanoparticles for improved diagnosis and treatment of pancreatic cancer
(2023-09-13)Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis with no effective treatment options. Several factors contribute to its lethality, including the usually late diagnosis in the already advanced stage and ... -
Cardiac fibroblast phenotype regulation in engineered connective tissues with a special focus on ER adaptation and stress
(2023-03-23)Cardiovascular diseases cause adverse myocardial remodeling due to cardiomyocyte loss and modifications to the extracellular matrix (ECM), which can ultimately lead to contractile dysfunction and pathological cardiac ... -
Novel therapeutic approaches to treat inflammatory conditions with glucocorticoid and calciferol nanoparticles in vivo and in vitro
(2023-01-10)The body is constantly confronted with environmental threats and sometimes the entry of pathogens leads to severe inflammatory conditions such as sepsis or acute lung injury (ALI). Both diseases are characterized by a ... -
Pre-Clinical Assessment of Cardiac and Lung Fibrosis Using Next Generation Imaging Modalities
(2022-03-08)Fibrosis, defined as an excessive deposition of connective tissue components causing disruption of the physiological architecture and organ malfunction, is commonly associated with high morbidity and mortality. The global ... -
The role of CRISPLD1 in the transition to heart failure
(2022-01-21)Heart failure is a leading cause of death worldwide. It is defined as a condition in which the heart is unable to pump a sufficient amount of blood through the body to satisfy its oxygen need and can be caused by various ... -
Exploring the role of LZTR1 in an autosomal recessive form of Noonan Syndrome by genome-edited induced pluripotent stem cells
(2021-10-22)Noonan syndrome is a multisystemic developmental disorder and is characterized by variable symptoms such as facial dysmorphisms, short stature, webbing of the neck and mild intellectual disability. The most severe clinical ... -
Mechanical regulation of cardiac fibroblasts.
(2021-08-09)Cardiac fibrosis progressively contributes to heart failure (HF). Yet, its complex nature still lacks a more comprehensive understanding. One main hurdle is the lack of representative human models providing insights into ... -
Immunotherapy of solid tumors: multimodal imaging strategies for chimeric antigen receptor T cell tracking in the tumor microenvironment
(2021-08-02)Immunotherapy is an emerging building block of modern oncology, after chimeric antigen receptor (CAR) T cells demonstrated groundbreaking survival rates in hematological malignancies. However, therapy success in more common ... -
An integrative and translational assessment of altered atrial electrophysiology, calcium handling and contractility in patients with atrial fibrillation
(2020-11-18)Atrial fibrillation (AF) is the most prevalent sustained arrhythmia reported in clinical practice, and it is associated with deleterious outcomes such as stroke, that increase patient morbidity and mortality. Previous ... -
Mechanisms of Glucocorticoids in the modulation of Graft-versus-Host Disease and the Graft-versus-Leukemia Reaction
(2020-07-31)Acute graft-versus-host disease (aGvHD) is a severe complication that frequently occurs after allogeneic hematopoietic stem cell transplantation and results in a high transplant-related morbidity and mortality. Glucocorticoids ... -
Analysis of the GPCR-induced RhoA signaling in healthy and diseased adult cardiomyocytes
(2019-04-10)Background: The aim of the presented thesis was to analyze the activation of the monomeric G protein RhoA in adult cardiomyocytes and further to unravel the role of the guanine nucleotide exchange factor p63RhoGEF in this ... -
Fibroblast-Cardiomyocyte Cross-Talk in Heart Muscle Formation and Function
(2019-02-01)Cardiac fibroblasts make up a considerable fraction of the total heart cell content. How cardiac fibroblasts signaling affects heart muscle function in normal heart development and disease remains, however, largely unresolved. ... -
Exosomes as Potential Transport Vehicles of Tetrahydrobiopterin, 6-Pyrovyoltetrahydrobiopterin-Synthase and Tripeptidyl-Peptidase I
(2018-12-14)Extracellular vesicles (EV) for the therapeutic application are of growing scientific interest. But even though the number of clinical trials on EVs almost doubled from 29 to 52 within 2017, the number of trials with ... -
Elucidating the pathomechanism behind the neurocristopathy CHARGE syndrome
(2018-02-26)CHARGE syndrome is a complex congenital malformation disorder, caused in more about two-thirds of the cases by heterozygous loss of function mutations in the chromodomain helicase DNA-binding protein 7 (CHD7). The acronym ... -
Development of a Rhesus macaque engineered heart muscle model from pluripotent stem cells
(2017-06-13)Myocardial infarction is the leading cause of death globally. Remuscularization of the heart with stem cell based treatments is one potential approach to heart repair which is presently being tested. Proof-of-concept ... -
Analysis of the function of the IGF1R during the development and therapy of colorectal cancer
(2016-12-06)The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase that is overexpressed in a variety of human malignancies, including colorectal cancer (CRC). In the present study, the role of the IGF1R during ... -
Investigation of immune responses contributing to the pathogenesis of load-induced heart failure and the rejection of stem cell grafts
(2016-08-24)Heart failure (HF) is often associated with inflammation and activation of the immune system. Moreover, the development to HF has been shown to be accompanied by autoimmune reactions since cardiac autoantibodies were ... -
Immunological properties of parthenogenetic stem cell derived cardiomyocytes and their application in cardiac tissue engineering
(2016-06-20)Cardiovascular diseases and their long term consequences constitute serious health and economic burdens. Although promising new therapeutic approaches to ameliorate the detrimental consequences have been introduced, there ...