Browsing Molekulare Medizin by Referee "Ebert, Antje PD Dr."
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Determination of CaMKII and PKA role in PLN R14del functional phenotype
(2025-10-16)Phospholamban (PLN) is a 52-amino acid tail-anchored transmembrane protein and an essential regulator in the cardiac excitation-contraction coupling (ECC) involved in the regulation of the Sarcoendoplasmatic Reticulum ... -
Interactome and Subcellular Analysis of the Tethering Proteins VAPA and VAPB in Cardiomyocytes
(2025-07-18)Heart muscle contraction is regulated by excitation-contraction-coupling (ECC), where calcium (Ca2+) released from the sarcoendoplasmic reticulum (SER) triggers myofilament contraction. The SER is crucial for intracellular ... -
Elucidating the Molecular Pathologies in Mouse Models for Mitochondrial Diseases
(2025-06-04)The field of exploring mitochondrial diseases has gained much attention and notoriety in recent years. Individual mutations in proteins involved in mitochondrial structure and function are rare. However, when taken as a ... -
The Functional Role of the Membrane Bending Ability of the Yeast PROPPINs
(2025-04-04)The meticulously regulated mechanism, which overseas processes of cellular breakdown and recycling, is called macroautophagy. It has been preserved from yeast to more advanced eukaryotic organisms. As a response to various ... -
Mild production of reactive oxygen species reversibly affects the metabolism and function of the heart
(2023-01-25)Reactive oxygen species (ROS) are molecular oxygen derivatives that are produced as an attribute of aerobic life. The relationship between elevated levels of ROS and heart failure (HF) has been extensively studied. However, ... -
Cellular response to compartmentalized redox alterations
(2022-08-24)Reactive oxygen species (ROS) were considered only as toxic and unavoidable by-products of aerobic cell life in the past. Nevertheless, their significance for cellular signalling is currently widely accepted and extensively ...