Browsing Molekulare Medizin by Referee "Kube, Dieter Prof. Dr."
Now showing items 1-15 of 15
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Spatial Architecture and Functional Characterization of Super Enhancer Associated Transcriptional Circuits in Aggressive Lymphomas
(2023-10-19)Aggressive lymphomas are clinically and biologically heterogenous entities, reflecting a diverse cell of-origins with multiple means of malignant transformation. With chemoimmunotherapy, a majority of patients suffering ... -
Melanoma-associated brain metastasis: Molecular mechanisms and therapeutic options
(2022-04-14)Melanoma is the deadliest of skin cancers and exhibits the highest level of brain tropism of all cancer types. Melanoma brain metastases (MBMs) are diagnosed in no less than 50 % of patients with stage IV melanoma, although ... -
Targeting JAK/STAT signalling for sensitization of colorectal cancer cells to chemoradiotherapy
(2021-07-08)Despite ever-evolving treatment and screening procedures, Colorectal cancer (CRC) remains a major cause of cancer-related deaths worldwide. Preoperative chemoradiotherapy (CRT), followed by standardized surgical resection ... -
EZH2-GATA6 axis in Pancreatic ductal adenocarcinoma
(2020-09-25)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease which is significantly driven by epigenetic alterations, e.g. installed by overexpression of Enhancer of Zeste homologue 2 (EZH2). EZH2 constitutes ... -
Mechanisms of Glucocorticoids in the modulation of Graft-versus-Host Disease and the Graft-versus-Leukemia Reaction
(2020-07-31)Acute graft-versus-host disease (aGvHD) is a severe complication that frequently occurs after allogeneic hematopoietic stem cell transplantation and results in a high transplant-related morbidity and mortality. Glucocorticoids ... -
Interplays and feedback loops of oncogenic signaling pathways in B cell non-Hodgkin lymphoma
(2019-02-28)The B cell receptor (BCR) signaling, required for the survival and maturation of B cells, is one major deregulated pathway in B cell lymphomas. Several mutations are known to enhance the tonic BCR signal in Burkitt lymphomas ... -
Targeting the Hedgehog and PI3K/AKT/mTOR signaling pathways in rhabdomyosarcoma
(2018-12-18)Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS, and especially the embryonal subtype (ERMS), show activation of Hedgehog (HH) signaling. In patients with Gorlin syndrome, ... -
Hodgkin lymphoma secreted factors determine macrophage polarization and function
(2018-09-14)Hodgkin lymphoma (HL) is a unique entity where the fraction of malignant cells accounts for only 1 % of the tumor. The cells are embedded in a complex background of non-neoplastic immune infiltrates. Profound interactions ... -
Therapeutic strategies targeting Kv10.1 in PDAC
(2017-01-19)This study was conducted to explore the suitability of the voltage gated potassium channel Kv10.1 as a novel therapeutic target in pancreatic ductal adenocarcinoma (PDAC). PDAC, which is characterized by marked invasiveness, ... -
The influence of valproic acid and the role of cyclin D2 in prostate cancer
(2016-10-11)Prostate cancer (PCa) is the most frequently new diagnosed cancer and the third leading cause of cancer-related deaths in men in Germany. Studies on possible agents for PCa therapy are indispensable since treatment options ... -
Analyse molekularer Marker und Signalwege in soliden Tumorzelllinien und ihre Bedeutung für die Tumorprogression und Metastasierung
(2016-06-01)The development of distant metastases is the main leading cause of cancer death and the crucial adverse event in cancer progression. The “Seed and Soil” hypothesis by Stephen Paget states that different cancer cells prefer ... -
The interaction between Hedgehog/Patched and Ras signaling in Rhabdomyosarcoma
(2016-03-15)Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. In children, the most common histological subtypes are embryonal RMS (ERMS) and alveolar RMS (ARMS). One feature of human RMS is aberrant Hedgehog ... -
Improving Therapies of Rhabdomyosarcoma
(2016-01-08)Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and occurs as two major subtypes; embryonal (ERMS) and alveolar RMS (ARMS). Therapies of RMS typically combine surgical excision or local irradiation ... -
Analyses on the mechanisms underlying the leupaxin-mediated progression of prostate cancer
(2015-08-19)The focal adhesion protein leupaxin (LPXN) is overexpressed in a subset of prostate cancers (PCa). Recently, LPXN was shown to be involved in the progression of prostate carcinomas. In the present study, the LPXN-mediated ... -
Chemokine receptors CXCR4 and CCR5: Cell surface expression, signaling and modulation by β-arrestin 2
(2015-02-26)G protein-coupled receptors which mediate a large variety of different cellular effects have always been a field of significant interest for pharmaceutical research. Since it was shown that the chemokine receptors CXCR4 ...