Browsing Molekulare Medizin by Referee "Nikolaev, Viacheslav Dr."
Now showing items 1-5 of 5
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Redox regulation of protein phosphatase-1 and ER stress regulation of connective tissue growth factor in cardiomyocytes
(2017-06-28)Heart failure is one of the most common causes for morbidity and hospitalization in the western civilization. The prognosis is still poor and new therapies are needed. For decades, variations in phosphorylation and redox ... -
Functional characterization of genetic polymorphisms in the organic cation transporter OCT1 with a special focus on the substrate-specific effects of the M420del polymorphism
(2016-06-06)The human organic cation transporter 1 (OCT1) is strongly expressed in the sinusoidal membrane of hepatocytes. OCT1 mediates the uptake of drugs and exogenous substances with cationic or weak basic structures into the ... -
Die Rolle der Phosphodiesterase 2 im Herzen
(2014-12-03)Heart failure is a worldwide health issue with high morbidity and mortality rates and always a poor prognostic outlook. A characteristic element of the molecular driven structural transformation, which precedes the ... -
Phosphodiesterases as Crucial Regulators of Cardiomyocyte cAMP in Health and Disease
(2014-11-13)Cyclic nucleotides are ubiquitous second messengers, which regulate cellular functions by acting in discrete subcellular microdomains. Cardiac phosphodiesterases (PDEs) are indispensable for -adrenoceptor signaling regulation ... -
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions
(2014-07-14)On molecular level, cells sense changes in oxygen availability through the prolyl-4-hydroxylase domain enzymes (PHDs), which in turn regulate the protein stability of the α-subunit of the transcription factor hypoxia-inducible ...