Browsing Molekulare Medizin by Referee "Rizzoli, Silvio Prof. Dr."
Now showing items 1-10 of 10
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High throughput strategies for electrophysiological characterisation of cardiomyocytes
(2023-08-22)Personalised medicine describes the customised application of medical treatment at a patient-specific level. This type of precision medicine stratifies patients based on their specific genotype or phenotype for targeted ... -
Cellular response to compartmentalized redox alterations
(2022-08-24)Reactive oxygen species (ROS) were considered only as toxic and unavoidable by-products of aerobic cell life in the past. Nevertheless, their significance for cellular signalling is currently widely accepted and extensively ... -
Peroxisomal calcium handling and homeostasis
(2022-04-26)Peroxisomes are ubiquitous cellular organelles in eukaryotes essential for metabolism. The close localization of peroxisomes with the sarcoplasmic reticulum and T-tubules is known from electron micrographs of rodent hearts. ... -
The Endogenous and Exogenous Substrate Spectrum of the Human Organic Cation Transporter OCT1 – a Comprehensive Characterization
(2021-07-23)The organic cation transporter 1 (OCT1) is most extensively expressed in the human liver. OCT1 is involved in the hepatic uptake of several drugs and endogenous compounds, which then undergo bioactivation, recycling, ... -
Understanding Secretory MVB Trafficking for the Release of Small Extracellular Vesicles
(2021-04-16)The release of small extracellular vesicles (sEVs) from multivesicular bodies (MVBs) represents an integral part of intercellular communication during development, homeostasis and disease. While secretory MVBs are ... -
Regional-dependent, comprehensive characterization of miRNA signatures in sporadic Creutzfeldt-Jakob Disease and early Alzheimer’s Disease-type neuropathology
(2019-10-09)The pathogenic mechanisms and the origins of neurodegenerative diseases remain unclear on molecular level. Increasing evidences postulate alterations in miRNA signatures as critical factor in pathogenesis, progression ... -
Exosomes as Potential Transport Vehicles of Tetrahydrobiopterin, 6-Pyrovyoltetrahydrobiopterin-Synthase and Tripeptidyl-Peptidase I
(2018-12-14)Extracellular vesicles (EV) for the therapeutic application are of growing scientific interest. But even though the number of clinical trials on EVs almost doubled from 29 to 52 within 2017, the number of trials with ... -
Dissecting the molecular function of the ubiquitin-like Atg8 during autophagosome biogenesis in S. cerevisiae
(2018-03-23)Autophagy is a degradative pathway that is conserved from yeast to mammals. Marcoautophagy is characterized by the formation of a unique double-membrane layered vesicle, the so-called autophagosome. Proteins and organelles ... -
Mechanisms of communication from mitochondria to lysosomes
(2017-03-24)The importance of mitochondria for cellular respiration, ATP synthesis and involvement in cell signaling pathways impacting cell proliferation, differentiation or death is now recognized. Due to the broad roles of mitochondria ... -
Characterization of peroxisomes and peroxisome deficient cell lines by super-resolution microscopy and biochemical methods
(2016-11-25)Stimulated Transmission Emission Depletion (STED) microscopy was used to characterize the nanoscopic morphology of wild-type peroxisomes under normal and proliferative conditions in mammalian cells and in yeast Saccharomyces ...