Browsing Molekulare Medizin by Referee "Schön, Michael P. Prof. Dr."
Now showing items 1-7 of 7
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Exploring molecular patterns and determinants of melanoma cell susceptibility to natural killer cell cytotoxicity
(2020-07-16)Malignant melanoma is the deadliest form of skin cancer. Due to its genetic heterogeneity and high potential to metastasize, the treatment of melanoma is challenging. Despite the promising result of T-cell based therapeutic ... -
Dynamics of Neutrophil Extracellular Trap (NET) Formation
(2019-12-03)Neutrophil granulocytes are the largest group of white blood cells and play a significant role in the innate immune system. With the discovery of a vast number of thus far unknown functions, neutrophil granulocytes became ... -
Functional relevance of spontaneous alternative splice variants of xeroderma pigmentosum genes: Prognostic marker for skin cancer risk and disease outcome?
(2017-05-05)The nucleotide excision repair (NER) pathway is a central DNA repair mechanism to repair a variety of bulky DNA lesions. Accumulation of these types of damage all over the genome results in the development of a cancer prone ... -
Immunological properties of parthenogenetic stem cell derived cardiomyocytes and their application in cardiac tissue engineering
(2016-06-20)Cardiovascular diseases and their long term consequences constitute serious health and economic burdens. Although promising new therapeutic approaches to ameliorate the detrimental consequences have been introduced, there ... -
The role of SNAP29 during epidermal differentiation
(2015-12-11)The human CEDNIK syndrome is caused by loss-of-function mutations in the SNAP29 gene, encoding a member of the SNARE family of proteins. So far, no Snap29-deficient mammalian animal models have been described for this rare ... -
Real time visualization of cGMP and cAMP dynamics in intact adult cardiomyocytes using new transgenic mice
(2015-01-26)cAMP and cGMP are important second messengers in the cardiovascular system. Previously, it has been demonstrated that the cardiac ryanodine receptor (RyR2) forms a microdomain associated with key contributors of cAMP ... -
Characterization of the multifunctional XPG protein during Nucleotide-excision-repair
(2014-06-03)Xeroderma pigmentosum (XP), a cancer model disease, is the perfect proof for the existing model of carcinogenesis activated by mutations. All patients share a defect in Nucleotide excision repair (NER). The gene, which is ...