Browsing Molekulare Medizin by Referee "Streckfuß-Bömeke, Katrin PD Dr."
Now showing items 1-4 of 4
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Exploring the role of LZTR1 in an autosomal recessive form of Noonan Syndrome by genome-edited induced pluripotent stem cells
(2021-10-22)Noonan syndrome is a multisystemic developmental disorder and is characterized by variable symptoms such as facial dysmorphisms, short stature, webbing of the neck and mild intellectual disability. The most severe clinical ... -
Modeling Takotsubo syndrome with patient-specific induced pluripotent stem cell-derived cardiomyocytes
(2021-10-18)Takotsubo syndrome (TTS) is a severe acute heart disease presumably caused by high catecholamine levels resulting in wall motion abnormalities of the left ventricle. Despite the severe phenotype of TTS, the exact disease ... -
Human induced pluripotent stem cell models used in the study of doxorubicin-induced cardiomyopathy
(2020-06-24)Doxorubicin (DOX) has been used for decades to treat hematopoietic and solid tumors, although, in a subset of cancer survivors, it causes cardiotoxicity decades after treatment. The mechanisms of anthracycline-induced ... -
The Role of the Insulin-like Growth Factor Binding Protein 5 (IGFBP5) in Cardiogenesis and Cardiac Remodelling
(2018-10-15)The importance of elucidating mechanisms of cardiac regulatory networks during cardiogenesis is underscored by the re-activation of fetal gene expression in the diseased adult heart. To further understand this phenomenon, ...