Browsing Molekulare Medizin by Referee "Thumm, Michael Prof. Dr."
Now showing items 1-5 of 5
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Knockdown of NEAT1 prevents lipid droplet accumulation in microglia after ischemic stroke via autophagy
(2023-10-06)Lipid droplets (LDs), lipid-storing organelles containing neutral lipids such as glycerolipids and cholesterol, are increasingly accepted as structural markers of inflammation. The nuclear paraspeckle assembly transcript ... -
The Role of Heat Shock Protein A4 (HSPA4) in the Heart
(2023-07-07)Non-ischemic cardiomyopathies may be caused by genetic mutations but may also result from cytotoxic influences of chemotherapeutic drugs and the accumulation of misfolded proteins. Heat shock protein A4 (HSPA4) ... -
Analysis of the organization and signaling capacity of the membrane IgE during its interaction with CD19 and CD23 in B lymphocytes
(2021-07-27)The predominant allergy type I (hypersensitivity reaction type I) poses an increasing health issue in industrialized countries over the last decades. A key mediator in the pathogenesis of hypersensitivity or allergic ... -
Identification and Characterization of autophagic and non-autophagic Interaction Partners of Atg18
(2021-06-03)The PROPPIN Atg18 belongs to the WD40 repeat containing family and folds into a typical seven-bladed beta-propeller. Conserved regions at blade 5 and 6 allow for binding to phosphatidylinositolphosphates and mediate the ... -
Dissecting molecular elements of mitophagy and the lysis of intravacuolar vesicles
(2015-10-26)Autophagy is an evolutionary conserved catabolic process essential for the recycling and removal of cytosolic components via the lysosome (vacuole). Macroautophagy is characterized by the formation of a double membrane-layered ...