Browsing Molekulare Medizin by Referee "Walter, Lutz Prof. Dr."
Now showing items 1-11 of 11
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Subcellular compartmentalization of signal elements and their re-distribution in resting and activated B cells
(2024-09-19)BCR activation triggers a complex network of pathways and cascades, shaping the fate of B cells. This process is influenced by co-receptors as well as co-stimulatory molecules, among others. Dysregulation in this process ... -
Pre-clinical assessment of the therapeutic efficacy of a nanovaccine in a mouse model of pancreatic cancer
(2024-08-09)Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest diseases with increasing incidence in developed countries. Due to the late diagnosis of PDAC, available treatments do not significantly improve patient survival. ... -
Novel therapeutic approaches to treat inflammatory conditions with glucocorticoid and calciferol nanoparticles in vivo and in vitro
(2023-01-10)The body is constantly confronted with environmental threats and sometimes the entry of pathogens leads to severe inflammatory conditions such as sepsis or acute lung injury (ALI). Both diseases are characterized by a ... -
The role of the Glucocorticoid Receptor in intestinal inflammation and tumorigenesis in a murine model of colitis and colitis-associated colorectal cancer
(2022-08-12)Ulcerative colitis (UC) is a life-threatening disease with constantly increasing incidence. Glucocorticoids (GCs) are one of the first choices for the treatment of this disease thanks to their anti-inflammatory action and ... -
Mechanisms of Glucocorticoids in the modulation of Graft-versus-Host Disease and the Graft-versus-Leukemia Reaction
(2020-07-31)Acute graft-versus-host disease (aGvHD) is a severe complication that frequently occurs after allogeneic hematopoietic stem cell transplantation and results in a high transplant-related morbidity and mortality. Glucocorticoids ... -
Human induced pluripotent stem cell models used in the study of doxorubicin-induced cardiomyopathy
(2020-06-24)Doxorubicin (DOX) has been used for decades to treat hematopoietic and solid tumors, although, in a subset of cancer survivors, it causes cardiotoxicity decades after treatment. The mechanisms of anthracycline-induced ... -
Elucidating the pathomechanism behind the neurocristopathy CHARGE syndrome
(2018-02-26)CHARGE syndrome is a complex congenital malformation disorder, caused in more about two-thirds of the cases by heterozygous loss of function mutations in the chromodomain helicase DNA-binding protein 7 (CHD7). The acronym ... -
Development of a Rhesus macaque engineered heart muscle model from pluripotent stem cells
(2017-06-13)Myocardial infarction is the leading cause of death globally. Remuscularization of the heart with stem cell based treatments is one potential approach to heart repair which is presently being tested. Proof-of-concept ... -
Myeloid corticoid receptors in CNS autoimmunity: Old targets for novel therapies
(2016-10-21)Since the 1950s, glucocorticoids (GCs) have been the most widely employed drugs in the treatment of inflammatory and autoimmune disorders, such as multiple sclerosis (MS). Short-time application of high-dose GCs is the ... -
Identification of genes regulated in target organs of acute graft versus host disease in different organs in different species
(2016-10-13)Major histocompatibility complex (MHC) matching is essential to reduce the risk of graft versus host disease (GvHD) but minor histocompatibility antigens (mHags) also affect the outcome of hematopoietic stem cell transplantation ... -
Investigation of immune responses contributing to the pathogenesis of load-induced heart failure and the rejection of stem cell grafts
(2016-08-24)Heart failure (HF) is often associated with inflammation and activation of the immune system. Moreover, the development to HF has been shown to be accompanied by autoimmune reactions since cardiac autoantibodies were ...